Tg(Alb1-a)86Ejmi
Transgene Detail

Summary

• Symbol: Tg(Alb1-a)86Ejmi
• Name: transgene insertion 86, Edward J Michaud
• MGI ID: MGI:3512788
• Synonyms: alb-agouti86, Tg(Alb1-a)86R
• Transgene: Tg(Alb1-a)86Ejmi Location: unknown
• Alliance: Tg(Alb1-a)86Ejmi page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-a)86Ejmi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	a (MGI:87853)

• Mutation details: The wild-type murine agouti cDNA was cloned into an expression construct under the regulation of the mouse albumin promoter. The polyA tail was derived from SV40. The expression cassette was injected into fertilized FVB/N oocytes, and hemizygote mice were maintained on the FVB/N background. This allele was derived from founder 86. Northern blot analysis showed transgene expression in the liver, but not in muscle, small intestine, brain or white adipose tissue. (J:90795)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Alb1-a)86Ejmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90795 Kuklin AI, et al., Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes. Mol Cancer. 2004 Jun 2;3(1):17
• All: 1 reference(s)