Tg(Alb1-a)83Ejmi
Transgene Detail

Summary

• Symbol: Tg(Alb1-a)83Ejmi
• Name: transgene insertion 83, Edward J Michaud
• MGI ID: MGI:3512795
• Synonyms: alb-agouti 83, Tg(Alb1-a)83R
• Transgene: Tg(Alb1-a)83Ejmi Location: unknown
• Alliance: Tg(Alb1-a)83Ejmi page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-a)83Ejmi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	a (MGI:87853)

• Mutation details: The wild-type murine agouti cDNA was cloned into an expression cassette involving the mouse Alb1 promoter and SV40 poly A sequences. This cassette was cloned into fertilized FVB/N oocytes and hemizygous mice were maintained on an FVB/N background. This allele was derived from founder 83. Northern blot analysis confirmed transgene expression in the liver. No expression was detected in muscle, small intestine, brain or white adipose tissue. (J:90795)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Alb1-a)83Ejmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90795 Kuklin AI, et al., Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes. Mol Cancer. 2004 Jun 2;3(1):17
• All: 1 reference(s)