Iigp1c MGI Mouse Gene Detail - MGI:3644953 - interferon inducible GTPase 1C

Symbol

Iigp1c
Name

interferon inducible GTPase 1C
Synonyms

Gm4951

Feature Type

protein coding gene
IDs

MGI:3644953
NCBI Gene: 240327
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr18:60345152-60380892 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.36 cM
Mapping Data

1 experiment

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644953	protein coding gene	Chr18:60345064-60381512 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0024425	protein coding gene	Chr18:57413200-57450563 (+)
AKR/J	MGP_AKRJ_G0024394	protein coding gene	Chr18:58999992-59057827 (+)
BALB/cJ	MGP_BALBcJ_G0028076	protein coding gene	Chr4:26662171-26671527 (+)
C3H/HeJ	MGP_C3HHeJ_G0024191	protein coding gene	Chr18:59231445-59264686 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024870	protein coding gene	Chr18:61664972-61697157 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022302	protein coding gene	Chr18:56915873-56923203 (+)
CAST/EiJ	MGP_CASTEiJ_G0023665	protein coding gene	Chr18:59263634-59295414 (+)
CBA/J	MGP_CBAJ_G0024161	protein coding gene	Chr18:63678953-63721402 (+)
DBA/2J	MGP_DBA2J_G0024291	protein coding gene	Chr18:57093917-57125723 (+)
FVB/NJ	MGP_FVBNJ_G0024258	protein coding gene	Chr18:56450703-56483217 (+)
LP/J	MGP_LPJ_G0024376	protein coding gene	Chr18:59788102-59824259 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024288	protein coding gene	Chr18:65279450-65327165 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024917	protein coding gene	Chr18:59145670-59195549 (+)
PWK/PhJ	MGP_PWKPhJ_G0023410	protein coding gene	Chr18:57197354-57200651 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023216	protein coding gene	Chr18:59656603-59666935 (+)
WSB/EiJ	MGP_WSBEiJ_G0023728	protein coding gene	Chr18:59032462-59064814 (+)

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MGI Vertebrate Homology

Iigp1c stringent orthology
1 mouse;2 rat;3 zebrafish
Gene Tree

Iigp1c

Diseases

1 with Iigp1c mouse models

Human Disease

Mouse Models

metabolic dysfunction-associated steatotic liver disease

IDs

View 3 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 4 alleles in 4 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

2
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit non-obese nonalcoholic fatty liver disease induced by a high-fat diet.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

35
RefSeq

8
UniProt

1
CCDS

CCDS29268.1

Ensembl

ENSMUSG00000073555 (Evidence)
NCBI Gene

240327

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073555	Ensembl Gene Model \| MGI Sequence Detail	35741	C57BL/6J	± kb
transcript	ENSMUST00000031549	Ensembl \| MGI Sequence Detail	2645	Not Applicable
polypeptide	ENSMUSP00000031549	Ensembl \| MGI Sequence Detail	406	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR007743 Immunity-related GTPases-like

IPR030385 IRG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 17

Diseases 1

Gene Ontology 2

Phenotypes 5
Earliest

J:145965 Burckstummer T, et al., An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol. 2009 Mar;10(3):266-72
Latest

J:333470 Zhang Z, et al., Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nat Commun. 2022 Jul 16;13(1):4136

TSS for Iigp1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151240	Chr18:60345042-60345105 (+)	-78 bp
Tssr151241	Chr18:60345161-60345194 (+)	26 bp
Tssr151242	Chr18:60345657-60345680 (+)	517 bp
Tssr151243	Chr18:60346142-60346177 (+)	1,008 bp
Tssr151244	Chr18:60346216-60346239 (+)	1,076 bp
Tssr151245	Chr18:60347884-60347913 (+)	2,747 bp
Tssr151246	Chr18:60355616-60355620 (+)	10,466 bp
Tssr151247	Chr18:60356402-60356408 (+)	11,253 bp
Tssr151248	Chr18:60359214-60359224 (+)	14,067 bp
Tssr151249	Chr18:60362759-60362763 (+)	17,609 bp
Tssr151250	Chr18:60364224-60364243 (+)	19,082 bp
Tssr151251	Chr18:60368883-60368887 (+)	23,733 bp
Tssr151252	Chr18:60371919-60371965 (+)	26,790 bp
Tssr151253	Chr18:60372002-60372038 (+)	26,868 bp
Tssr151254	Chr18:60375966-60375972 (+)	30,817 bp
Tssr151255	Chr18:60379117-60379136 (+)	33,975 bp
Tssr151256	Chr18:60379669-60379701 (+)	34,533 bp
Tssr151257	Chr18:60379786-60379807 (+)	34,645 bp
Tssr151258	Chr18:60380347-60380361 (+)	35,202 bp
Tssr151259	Chr18:60380395-60380410 (+)	35,251 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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