Tg(ILK3mHEL)3Ccg
Transgene Detail

Summary

• Symbol: Tg(ILK3mHEL)3Ccg
• Name: transgene insertion 3, Christopher C Goodnow
• MGI ID: MGI:2385454
• Synonyms: ILK-3, ILK-3 Ins-HEL, insHEL, RIP-HEL, RIP-mHEL
• Transgene: Tg(ILK3mHEL)3Ccg Location: unknown
• Alliance: Tg(ILK3mHEL)3Ccg page

Transgene origin

• Strain of Origin: C57BL/6JSfd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ILK3mHEL)3Ccg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	LYZ (396218)

• Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 600bp fragment of the rat insulin promoter and to the mouse H2-K^b transmembrane sequence (which included the extracellularspacer sequence, transmembrane segment, and cytoplasmic tail). The rat insulin promoter was used to direct expression of the inserted sequence specifically to pancreatic islet beta cells. Islets from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, thyroid, and thymus did not. (J:78309, J:156091)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available

References

• Original: J:78309 Akkaraju S, et al., A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997 Aug;7(2):255-71
• All: 28 reference(s)