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Del(11Irf1-D11Mit23)1Rub Cytogenetic Marker Detail
Summary
  • Symbol
    Del(11Irf1-D11Mit23)1Rub
  • Name
    deletion, Chr 11, Edward M Rubin 1
  • Synonyms
    del11, Del(11Irf1-Csf2)1Rub, Del1Rub
  • Feature Type
    cytogenetic marker
  • IDs
    MGI:3614963
Location &
Maps
more
  • Sequence Map
    Chr11:53770014-54236047 bp
  • From MGI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, Syntenic
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Deletion homozygotes exhibit growth retardation, enlargement of the heart and liver, severe hypertriglyceridemia due to several-fold elevated hepatic secretion of very low density lipoprotein (VLDL) triglycerides, and premature death.
References
more
  • Summaries
    All 2
    Phenotypes 1
  • Earliest
    J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory