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Del(1)1Brk Cytogenetic Marker Detail
Summary
  • Symbol
    Del(1)1Brk
  • Name
    deletion, Chr 1, Jane Barker 1
  • Synonyms
    nm1054
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:3608907
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
more
  • Diseases
    1 with Del(1)1Brk mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 1 allele in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for this spontaneous deletion exhibit hypochromic, microcytic anemia associated with impaired iron uptake, small body size, and male infertility. Survival and hydroencephaly formation are sensitive to genetic background.
References
more
  • Summaries
    All 10
    Diseases 1
    Phenotypes 9
  • Earliest
    J:100202 Ohgami RS, et al., nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood. 2005 Nov 15;106(10):3625-31
  • Latest
    J:307547 Miyata H, et al., Analysis of the sperm flagellar axoneme using gene-modified mice. Exp Anim. 2020 Nov 12;69(4):374-381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory