Tg(Gdf5-cre,-ALPP)1Kng
Transgene Detail

Summary

• Symbol: Tg(Gdf5-cre,-ALPP)1Kng
• Name: transgene insertion 1, David M Kingsley
• MGI ID: MGI:3577961
• Synonyms: CAG(A), Gdf5-Cre
• Transgene: Tg(Gdf5-cre,-ALPP)1Kng Location: unknown
• Alliance: Tg(Gdf5-cre,-ALPP)1Kng page

Joint defects in Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gdf5-cre,-ALPP)1Kng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Gdf5

• Mutation details: This transgene contains Cre recombinase and human placental alkaline phosphatase under the control of Gdf5 promoter and enhancer elements. A BAC containing the Gdf5 locus was modified by the insertion of a cre-IRES-ALPP into the translational start site to create the transgene. Gdf5 drives expression in developing joints. This line represents three that were created. (J:97780)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gdf5 (species not specified) Summary of all recombinase alleles driven by Gdf5. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

23 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:97780 Rountree RB, et al., BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol. 2004 Nov;2(11):e355
• All: 23 reference(s)