Tg(CD2-Il2rb)A-1Ttg
Transgene Detail

Summary

• Symbol: Tg(CD2-Il2rb)A-1Ttg
• Name: transgene insertion A-1, Tadatsugu Taniguchi
• MGI ID: MGI:3054884
• Synonyms: IL-2Rb A mutant, IL-2Rbetac deltaA-mutant, Tg(CD2-Il2rb-deltaLeu316-Leu385)1Ttg, Tg(Il2rb)A
• Transgene: Tg(CD2-Il2rb)A-1Ttg Location: unknown
• Alliance: Tg(CD2-Il2rb)A-1Ttg page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Il2rb)A-1Ttg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il2rb (MGI:96550)

• Mutation details: A cDNA encoding mouse interleukin 2 receptor beta lacking amino acids 316 through 385 - the acidic (A-) region - of the extracellular domain of the mature protein was inserted into an expression vector containing 5 kb of 5' flanking sequence, including the promoter, transcription initiation site and first intron, and 5.5 kb of 3' flanking sequence including the locus control region (LCR) of the human CD2 gene. The CD2 promoter/enhancer direct expression in cells of the lymphoid lineage. (J:92915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92915 Fujii H, et al., Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations. EMBO J. 1998 Nov 16;17(22):6551-7
• All: 1 reference(s)