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Sls Gene Detail
Summary
  • Symbol
    Sls
  • Name
    semidominant lethal spotting
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:3045162
Location & Maps
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  • Genetic Map
    Chromosome 2, Syntenic
  • Mapping Data
    1 experiment
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this spontaneous mutation have large areas of white spotting by weaning age and display lethal megacolon with incomplete penetrance. Heterozygotes have small white spots on their belly and display hydronephrosis and hydroencephaly with incompete penetrance.
References
more
  • Summaries
    All 1
    Phenotypes 1
  • Earliest
    J:91387 Harris BS, et al., A new mouse mutation named Semidominant lethal spotting is mapped to Chromosome 2. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2004;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory