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Lrit3 Gene Detail
Summary
  • Symbol
    Lrit3
  • Name
    leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
  • Synonyms
    LOC242235
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685267
    NCBI Gene: 242235
  • Gene Overview
    MyGene.info: LRIT3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129788291-129804030 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685267
protein coding gene Chr3:129787881-129804030 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027872
protein coding gene Chr3:132468628-132485055 (-)
A/J MGP_AJ_G0027830
protein coding gene Chr3:127858355-127874445 (-)
AKR/J MGP_AKRJ_G0027795
protein coding gene Chr3:131169431-131185816 (-)
BALB/cJ MGP_BALBcJ_G0027843
protein coding gene Chr3:127698985-127715617 (-)
C3H/HeJ MGP_C3HHeJ_G0027572
protein coding gene Chr3:131562696-131581033 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028287
protein coding gene Chr3:137201341-137217433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025625
protein coding gene Chr3:123383085-123399908 (-)
CAST/EiJ MGP_CASTEiJ_G0027029
protein coding gene Chr3:131241073-131258109 (-)
CBA/J MGP_CBAJ_G0027548
protein coding gene Chr3:141813811-141829935 (-)
DBA/2J MGP_DBA2J_G0027689
protein coding gene Chr3:127049609-127065770 (-)
FVB/NJ MGP_FVBNJ_G0027656
protein coding gene Chr3:124636522-124652934 (-)
LP/J MGP_LPJ_G0027798
protein coding gene Chr3:133974143-133991720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027687
protein coding gene Chr3:149773828-149790109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028344
protein coding gene Chr3:130843469-130859666 (-)
PWK/PhJ MGP_PWKPhJ_G0026753
protein coding gene Chr3:126785798-126802204 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026578
protein coding gene Chr3:128903624-128921535 (-)
WSB/EiJ MGP_WSBEiJ_G0027108
protein coding gene Chr3:131555619-131571952 (-)



Homology
more
  • Human Ortholog
    LRIT3, leucine rich repeat, Ig-like and transmembrane domains 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRIT3, leucine rich repeat, Ig-like and transmembrane domains 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSNB1F, FIGLER4
  • Links
    NCBI Gene ID: 345193
    neXtProt AC: NX_Q3SXY7
    UniProt: Q3SXY7

  • Chr Location
    4q25; chr4:109848182-109872315 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 19426
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRIT3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrit3 mouse models; 1 with human LRIT3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele show a selective absence of the ERG b-wave with a normal a-wave component under scotopic conditions, as well as variable ERG responses with larger a-wave amplitudes, shorter b-wave amplitudes, and longer implicit times of both waves under photopic conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242235 NCBI Gene Model | MGI Sequence Detail 15740 C57BL/6J ±  kb
    transcript NM_001287224 RefSeq | MGI Sequence Detail 2046 C57BL/6  
    polypeptide W8DXL4 UniProt | EBI | MGI Sequence Detail 681 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:241495 Charette JR, et al., A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. Adv Exp Med Biol. 2016;854:177-83

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory