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Lrit3 Gene Detail
Summary
  • Symbol
    Lrit3
  • Name
    leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
  • Synonyms
    LOC242235
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685267
    NCBI Gene: 242235
  • Gene Overview
    MyGene.info: LRIT3
Location & Maps
more
  • Sequence Map
    Chr3:129787881-129804030 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16150 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 58.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LRIT3, leucine rich repeat, Ig-like and transmembrane domains 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRIT3, leucine rich repeat, Ig-like and transmembrane domains 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNB1F, FIGLER4
  • Links
    NCBI Gene ID: 345193
    neXtProt AC: NX_Q3SXY7

  • Chr Location
    4q25; chr4:109848184-109872315 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 19426
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LRIT3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrit3 mouse models; 1 with human LRIT3 associations

Human Disease Mouse Models
       Night Blindness, Congenital Stationary, Type 1F; CSNB1F   OMIM: 615058 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Lrit3
  • Incidental Mutations
    APF
Mice homozygous for a targeted allele show a selective absence of the ERG b-wave with a normal a-wave component under scotopic conditions, as well as variable ERG responses with larger a-wave amplitudes, shorter b-wave amplitudes, and longer implicit times of both waves under photopic conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase lrit3
    ZFIN lrit3b
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045099 VEGA Gene Model | MGI Sequence Detail 16150 C57BL/6J ±  kb
transcript OTTMUST00000118505 VEGA | MGI Sequence Detail 2456 Not Applicable  
polypeptide OTTMUSP00000066145 VEGA | MGI Sequence Detail 681 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    271 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 16
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:143398 Homma S, et al., Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns. 2009 Jan;9(1):1-26
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory