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Trim58 Gene Detail
Summary
  • Symbol
    Trim58
  • Name
    tripartite motif-containing 58
  • Synonyms
    LOC216781, LOC386443
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684862
    NCBI Gene: 216781
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:58531291-58543230 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 36.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684862
 protein coding gene Chr11:58531232-58543277 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018366
 protein coding gene Chr11:58383887-58398031 (+)
A/J MGP_AJ_G0018336
 protein coding gene Chr11:56126000-56137902 (+)
AKR/J MGP_AKRJ_G0018305
 protein coding gene Chr11:57996319-58010076 (+)
BALB/cJ MGP_BALBcJ_G0018306
 protein coding gene Chr11:56482208-56495539 (+)
C3H/HeJ MGP_C3HHeJ_G0018118
 protein coding gene Chr11:57913383-57925225 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018757
 protein coding gene Chr11:60174947-60186858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016406
 protein coding gene Chr11:53473322-53486018 (+)
CAST/EiJ MGP_CASTEiJ_G0017683
 protein coding gene Chr11:58012452-58026379 (+)
CBA/J MGP_CBAJ_G0018093
 protein coding gene Chr11:62929436-62941248 (+)
DBA/2J MGP_DBA2J_G0018202
 protein coding gene Chr11:55793405-55805193 (+)
FVB/NJ MGP_FVBNJ_G0018193
 protein coding gene Chr11:55481213-55492995 (+)
LP/J MGP_LPJ_G0018275
 protein coding gene Chr11:58930214-58943188 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018218
 protein coding gene Chr11:64011756-64024186 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018800
 protein coding gene Chr11:58038306-58055352 (+)
PWK/PhJ MGP_PWKPhJ_G0017455
 protein coding gene Chr11:56402126-56414648 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017729
 protein coding gene Chr11:57699016-57711010 (+)



Homology
more
  • Human Ortholog
    TRIM58, tripartite motif containing 58
  • Vertebrate Orthologs
    19
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM58, tripartite motif containing 58
  • Synonyms
    BIA2
  • Links
    NCBI Gene ID: 25893
    neXtProt AC: NX_Q8NG06
    UniProt: Q8NG06

  • Chr Location
    1q44; chr1:247857187-247880138 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit no overt phenotype but show delayed resolution of DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037124 Ensembl Gene Model | MGI Sequence Detail 11940 C57BL/6J ±  kb
    transcript ENSMUST00000075084 Ensembl | MGI Sequence Detail 2192 Not Applicable  
    polypeptide ENSMUSP00000074594 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2686629
    References
    more
    • Summaries
      All 21
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:279270 Eyking A, et al., TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. J Immunol. 2019 Sep 15;203(6):1636-1649
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory