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Plch1 Gene Detail
Summary
  • Symbol
    Plch1
  • Name
    phospholipase C, eta 1
  • Synonyms
    MGC:57096, PLCeta1, Plcl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683547
    NCBI Gene: 269437
Location & Maps
more
  • Sequence Map
    Chr3:63696234-63899472 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      203239 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.08 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLCH1, phospholipase C eta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLCH1, phospholipase C eta 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PLCL3
  • Links
    NCBI Gene ID: 23007
    neXtProt AC: NX_Q4KWH8

  • Chr Location
    3q25.31; chr3:155479881-155745089 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 88833
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PLCH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Plch1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030810 VEGA Gene Model | MGI Sequence Detail 203239 C57BL/6J ±  kb
transcript OTTMUST00000076251 VEGA | MGI Sequence Detail 6245 Not Applicable  
polypeptide OTTMUSP00000040114 VEGA | MGI Sequence Detail 1682 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1064 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000012838 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
  • EC
  • InterPro Domains
    IPR028392 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    IPR000008 C2 domain
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR011993 PH domain-like
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 50
    cDNA 50

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory