Tg(APOA4)8018Feb
Transgene Detail

Summary

• Symbol: Tg(APOA4)8018Feb
• Name: transgene insertion 8018, Francisco E Baralle
• MGI ID: MGI:2652473
• Transgene: Tg(APOA4)8018Feb Location: unknown
• Alliance: Tg(APOA4)8018Feb page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOA4)8018Feb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOA4 (337)

  Apoa4

  (MGI:88051)

• Mutation details: The transgene construct comprises the human APOA4 gene with ~7 kb of 5'- and 6 kb of 3'- flanking genomic DNA. This transgenic line was estimated by densitrometric Southern blot analysis to carry ~9 copies of the construct. Human APOA4 protein was detected in plasma of these mice at ~11 times the level in human plasma. Like the endogenous transcript, transgene-derived human Apoa4 mRNA was present at significant levels in liver and at much higher levels in intestine. (J:82359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Nine copies of the transgene inserted into the genome.

References

• Original: J:82359 Baralle M, et al., Regulation of the human apolipoprotein AIV gene expression in transgenic mice. FEBS Lett. 1999 Feb 19;445(1):45-52
• All: 1 reference(s)