Prss35 MGI Mouse Gene Detail - MGI:2444800

Symbol

Prss35
Name

serine protease 35
Synonyms

6030424L22Rik

Feature Type

protein coding gene
IDs

MGI:2444800
NCBI Gene: 244954
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:86625702-86640496 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 46.58 cM
Mapping Data

1 experiment

SNPs within 2kb

454 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444800	protein coding gene	Chr9:86625291-86640496 (+)
129S1/SvImJ	ENSMUSG00200005368	protein coding gene	Chr9:83751126-83765926 (+)
A/J	ENSMUSG00195007289	protein coding gene	Chr9:83532786-83547450 (+)
AKR/J	ENSMUSG00220019198	protein coding gene	Chr9:83659094-83673835 (+)
BALB/cJ	ENSMUSG00180006881	protein coding gene	Chr9:83637675-83652342 (+)
C3H/HeJ	ENSMUSG00175004673	protein coding gene	Chr9:83697271-83711936 (+)
C57BL/6NJ	ENSMUSG00215006978	protein coding gene	Chr9:83632493-83647290 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032499	protein coding gene	Chr9:83317550-83319679 (+)
CAST/EiJ	ENSTCUG00005003857	protein coding gene	Chr9:83228577-83243343 (+)
CBA/J	ENSMUSG00210005782	protein coding gene	Chr9:83751143-83765945 (+)
DBA/2J	ENSMUSG00185001551	protein coding gene	Chr9:83762190-83776933 (+)
FVB/NJ	ENSMUSG00205004442	protein coding gene	Chr9:83938886-83953626 (+)
JF1/MsJ	ENSUMUG00000017542	protein coding gene	Chr9:83632407-83646707 (+)
LP/J	ENSMUSG00230009387	protein coding gene	Chr9:83881992-83896791 (+)
NOD/ShiLtJ	ENSMUSG00190011010	protein coding gene	Chr9:83832642-83847383 (+)
NZO/HlLtJ	ENSMUSG00225015553	protein coding gene	Chr9:84063110-84077853 (+)
PWK/PhJ	ENSLUMG00010002669	protein coding gene	Chr9:83566753-83581087 (+)
SPRET/EiJ	ENSMSPG00010002474	protein coding gene	Chr9:85010434-85022671 (+)
WSB/EiJ	ENSIUOG00005003390	protein coding gene	Chr9:83226063-83240373 (+)

Human Ortholog

PRSS35, serine protease 35

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRSS35, serine protease 35
Synonyms

C6orf158, dJ223E3.1
Links

HGNC:21387

NCBI Gene ID: 167681

UniProt: Q8N3Z0
Chr Location

6q14.2; chr6:83512508-83525704 (+) GRCh38

MGI Vertebrate Homology

Prss35 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRSS35
Gene Tree

Prss35

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Prss35
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit no detectable abnormal phenotype.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

19
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prss35

ZFIN prss35

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All Sequences

42
RefSeq

8
UniProt

1
CCDS

CCDS40714.1

Ensembl

ENSMUSG00000033491 (Evidence)
NCBI Gene

244954

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033491	Ensembl Gene Model \| MGI Sequence Detail	14795	C57BL/6J	± kb
transcript	ENSMUST00000036426	Ensembl \| MGI Sequence Detail	3444	Not Applicable
polypeptide	ENSMUSP00000035271	Ensembl \| MGI Sequence Detail	409	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013327 inactive serine protease 35

(term hierarchy)
InterPro Domains

IPR050966 Glutamyl Endopeptidase

IPR009003 Peptidase S1, PA clan

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR001254 Serine proteases, trypsin domain
GlyGen

Q8C0F9 1 site

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 14
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prss35:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86399	Chr9:86625301-86625334 (+)	-384 bp
Tssr86400	Chr9:86625669-86625691 (+)	-22 bp
Tssr86401	Chr9:86625694-86625707 (+)	-1 bp
Tssr2957	Chr9:86625713-86625722 (+)	16 bp
Tssr86402	Chr9:86639922-86639924 (+)	14,221 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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