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Suv420h1
Gene Detail
Symbol

Name
ID
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
MGI:2444557
Synonyms
C630029K18Rik, KMT5B, Suv4-20h1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:3767421-3818302 bp, + strand
From VEGA annotation of GRCm38

  50882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Suv420h1

Human
homologs
Human Homolog SUV420H1, suppressor of variegation 4-20 homolog 1 (Drosophila)
NCBI Gene ID 51111
neXtProt AC  NX_Q4FZB7
Human Synonyms  CGI85, KMT5B
Human Chr (Location)  11q13.2; chr11:68154863-68213783 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
 
Interactions
Suv420h1 interacts with 403 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (132)    Tissues (123)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Northern blot 14
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017297 VEGA Gene Model | MGI Sequence Detail 50882 C57BL/6J ±  kb
transcript OTTMUST00000041957 VEGA | MGI Sequence Detail 4159 Not Applicable 
polypeptide OTTMUSP00000018868 VEGA | MGI Sequence Detail 883 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(26) UniProt(11)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
InterPro IPR001214 SET domain
Protein Ontology PR:000015846 histone-lysine N-methyltransferase SUV420H1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(40)
Other
accession IDs
MGI:3034400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory