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Kmt5b Gene Detail
Summary
  • Symbol
    Kmt5b
  • Name
    lysine methyltransferase 5B
  • Synonyms
    C630029K18Rik, Suv420h1, Suv4-20h1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444557
    NCBI Gene: 225888
  • Gene Overview
    MyGene.info: KMT5B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:3767421-3818302 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.50 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI85, CGI-85, MRD51, SUV420H1
  • Links
    NCBI Gene ID: 51111
    neXtProt AC: NX_Q4FZB7
    UniProt: Q4FZB7

  • Chr Location
    11q13.2; chr11:68154863-68213904 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32351
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KMT5B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KMT5B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017297 VEGA Gene Model | MGI Sequence Detail 50882 C57BL/6J ±  kb
    transcript OTTMUST00000041957 VEGA | MGI Sequence Detail 4159 Not Applicable  
    polypeptide OTTMUSP00000018868 VEGA | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      156 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:3034400
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:243553 Fisher CL, et al., An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Res. 2017 Dec 1;45(21):e174

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory