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Suv420h1
Gene Detail
 Symbol
Name
ID
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
MGI:2444557
Synonyms C630029K18Rik, KMT5B, Suv4-20h1
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:3767421-3818302 bp, + strand
From VEGA annotation of GRCm38

  50882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Suv420h1

Human
homologs
Human Homolog SUV420H1, suppressor of variegation 4-20 homolog 1 (Drosophila)
NCBI Gene ID 51111
neXtProt AC  NX_Q4FZB7
Human Synonyms  CGI85, KMT5B
Human Chr (Location)  11q13.2; chr11:68154863-68213783 (-)  GRCh38
Alleles
and
phenotypes
All alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin modification, histone H4-K20 methylation, ...
Component chromosome, condensed nuclear chromosome, centromeric region, ...
Function histone-lysine N-methyltransferase activity, histone methyltransferase activity (H4-K20 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (132)    Tissues (123)    Images (2)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 118
Northern blot 14
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000017297 (Evidence)
Ensembl Gene ModelENSMUSG00000045098 (Evidence)
Entrez Gene225888 (Evidence)
DFCITC1578145, TC1587431, TC1587869, TC1589642, TC1594444, TC1596357, TC1604826, TC1613476
DoTSDT.101178781, DT.101189609, DT.101398255, DT.101737309, DT.40174610, DT.482767, DT.91398149, DT.94302041, DT.94302050
NIA Mouse Gene IndexU038766
EC2.1.1.43
PDB4BUP
Consensus CDS ProjectCCDS29399.1, CCDS50343.1, CCDS50344.1, CCDS50345.1
International Mouse Knockout Project StatusSuv420h1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017297 VEGA Gene Model | MGI Sequence Detail 50882 C57BL/6J ±  kb
transcript OTTMUST00000041957 VEGA | MGI Sequence Detail 4159 Not Applicable 
polypeptide OTTMUSP00000018868 VEGA | MGI Sequence Detail 883 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(26) UniProt(6)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
InterPro IPR001214 SET domain
Protein Ontology PR:000015846 histone-lysine N-methyltransferase SUV420H1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(40)
Other
accession IDs
MGI:3034400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory