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Suv420h1
Gene Detail
Symbol

Name
ID
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
MGI:2444557
Synonyms
C630029K18Rik, KMT5B, Suv4-20h1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:3767421-3818302 bp, + strand
From VEGA annotation of GRCm38

  50882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SUV420H1
Gene Tree: Suv420h1

Human
homologs
SUV420H1, suppressor of variegation 4-20 homolog 1 (Drosophila)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51111
neXtProt AC: NX_Q4FZB7

Human Synonyms: CGI85, CGI-85, KMT5B

Human Chr (Location): 11q13.2; chr11:68154863-68213783 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
 
Interactions
Suv420h1 interacts with 403 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (132)    Tissues (123)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Northern blot 14
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase suv420h1 ; ZFIN suv420h1    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000017297 (Evidence)
Ensembl Gene Model ENSMUSG00000045098 (Evidence)
Entrez Gene 225888 (Evidence)
DFCI TC1587431, TC1578145, TC1587869, TC1604826, TC1589642, TC1594444, TC1596357, TC1613476
DoTS DT.482767, DT.101737309, DT.40174610, DT.101398255, DT.101189609, DT.101178781, DT.91398149, DT.94302041, DT.94302050
NIA Mouse Gene Index U038766
EC 2.1.1.43
PDB 4BUP
Consensus CDS Project CCDS29399.1, CCDS50343.1, CCDS50344.1, CCDS50345.1
International Mouse Phenotyping Consortium Status Suv420h1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017297 VEGA Gene Model | MGI Sequence Detail 50882 C57BL/6J ±  kb
transcript OTTMUST00000041957 VEGA | MGI Sequence Detail 4159 Not Applicable 
polypeptide OTTMUSP00000018868 VEGA | MGI Sequence Detail 883 Not Applicable 

For the selected sequences
All sequences(143) RefSeq(36) UniProt(6)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
InterPro IPR001214 SET domain
Protein Ontology PR:000015846 histone-lysine N-methyltransferase SUV420H1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
All references(39)
Other
accession IDs
MGI:3034400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory