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Suv420h1 Gene Detail
Summary
  • Symbol
    Suv420h1
  • Name
    suppressor of variegation 4-20 homolog 1 (Drosophila)
  • Synonyms
    C630029K18Rik, KMT5B, Suv4-20h1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444557
    NCBI Gene: 225888
  • Gene Overview
    MyGene.info: KMT5B
Location & Maps
more
  • Sequence Map
    Chr19:3767421-3818302 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.50 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KMT5B, lysine methyltransferase 5B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI85, CGI-85, SUV420H1
  • Links
    NCBI Gene ID: 51111
    neXtProt AC: NX_Q4FZB7

  • Chr Location
    11q13.2; chr11:68154863-68213783 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at sub-Mendelian ratios, are smaller than control littermates, and die within a few hours of birth, probably due to alveolar defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017297 VEGA Gene Model | MGI Sequence Detail 50882 C57BL/6J ±  kb
transcript OTTMUST00000041957 VEGA | MGI Sequence Detail 4159 Not Applicable  
polypeptide OTTMUSP00000018868 VEGA | MGI Sequence Detail 883 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 8
Other
Accession IDs
less
MGI:3034400
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:183069 Wongtawan T, et al., Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory