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Brip1
Gene Detail
Symbol

Name
ID
Brip1
BRCA1 interacting protein C-terminal helicase 1
MGI:2442836
Synonyms
3110009N10Rik, 8030460J03Rik, BACH1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:86058138-86201193 bp, - strand
From VEGA annotation of GRCm38

  143056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Brip1

Human
homologs
Human Homolog BRIP1, BRCA1 interacting protein C-terminal helicase 1
NCBI Gene ID 83990
neXtProt AC  NX_Q9BX63
Human Synonyms  BACH1, FANCJ, OF
Human Chr (Location)  17q22.2; chr17:61679186-61863559 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human BRIP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Brip1 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, nuclear membrane, ...
Function 4 iron, 4 sulfur cluster binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (87)    Tissues (8)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 87
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000001045 (Evidence)
Ensembl Gene ModelENSMUSG00000034329 (Evidence)
Entrez Gene237911 (Evidence)
UniGene186143
DFCITC1661246, TC1581686
DoTSDT.94225707, DT.110522724, DT.91336630
NIA Mouse Gene IndexU033218
EC3.6.4.13
Consensus CDS ProjectCCDS25197.1
International Mouse Knockout Project StatusBrip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001045 VEGA Gene Model | MGI Sequence Detail 143056 C57BL/6J ±  kb
transcript OTTMUST00000002085 VEGA | MGI Sequence Detail 6931 Not Applicable 
polypeptide OTTMUSP00000001009 VEGA | MGI Sequence Detail 1174 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006555 ATP-dependent helicase, C-terminal
InterPro IPR010614 DEAD2
InterPro IPR013020 DNA helicase (DNA repair), Rad3 type
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000004816 Fanconi anemia group J protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213861 Peng M, et al., Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J. 2014 Aug 1;33(15):1698-712
All references(34)
Other
accession IDs
MGI:1920358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory