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Dis3l2
Gene Detail
Symbol

Name
ID
Dis3l2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
MGI:2442555
Synonyms
4930429A22Rik, 8030493P09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
43.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:86703808-87050095 bp, + strand
From VEGA annotation of GRCm38

  346288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DIS3L2
Gene Tree: Dis3l2

Human
homologs
DIS3L2, DIS3 like 3'-5' exoribonuclease 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 129563
neXtProt AC: NX_Q8IYB7

Human Synonyms: FAM6A, hDIS3L2, PRLMNS

Human Chr (Location): 2q37.1; chr2:231961583-232343968 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DIS3L2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dis3l2 interacts with 109 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoplasmic exosome (RNase complex), ...
Function 3'-5'-exoribonuclease activity, 5'-3' exoribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (106)    Tissues (18)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dis3l2 ; ZFIN dis3l2    NEW 
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048134 (Evidence)
Ensembl Gene Model ENSMUSG00000053333 (Evidence)
Entrez Gene 208718 (Evidence)
UniGene 389152
DFCI TC1624121, TC1617519, TC1594313, TC1613739, TC1590777, TC1577057
DoTS DT.55197990, DT.55128628, DT.110930953, DT.101350638, DT.102556957, DT.91349485, DT.99848031, DT.99848030, DT.94206251
NIA Mouse Gene Index U042185
EC 3.1.13.-
PDB 4PMW
Consensus CDS Project CCDS15124.1, CCDS48304.1
International Mouse Phenotyping Consortium Status Dis3l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048134 VEGA Gene Model | MGI Sequence Detail 346288 C57BL/6J ±  kb
transcript OTTMUST00000123633 VEGA | MGI Sequence Detail 3154 Not Applicable 
polypeptide OTTMUSP00000067456 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(981 from dbSNP Build 137)    SNPs within 2kb including multiple locations(983)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022966 Ribonuclease II/R, conserved site
Protein Ontology PR:000006493 DIS3-like exonuclease 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214591 Faehnle CR, et al., Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature. 2014 Oct 9;514(7521):252-6
All references(34)
Other
accession IDs
MGI:1924801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory