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Dis3l2
Gene Detail
Symbol

Name
ID
Dis3l2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
MGI:2442555
Synonyms
4930429A22Rik, 8030493P09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
43.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:86703808-87050095 bp, + strand
From VEGA annotation of GRCm38

  346288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dis3l2

Human
homologs
Human Homolog DIS3L2, DIS3 like 3'-5' exoribonuclease 2
NCBI Gene ID 129563
neXtProt AC  NX_Q8IYB7
Human Synonyms  FAM6A, hDIS3L2, PRLMNS
Human Chr (Location)  2q37.1; chr2:231961583-232343968 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DIS3L2
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dis3l2 interacts with 109 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoplasmic mRNA processing body
Function 3'-5'-exoribonuclease activity, 5'-3' exoribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (106)    Tissues (18)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048134 (Evidence)
Ensembl Gene ModelENSMUSG00000053333 (Evidence)
Entrez Gene208718 (Evidence)
UniGene389152
DFCITC1577057, TC1590777, TC1617519, TC1613739, TC1594313, TC1624121
DoTSDT.99848031, DT.99848030, DT.91349485, DT.94206251, DT.55197990, DT.55128628, DT.110930953, DT.101350638, DT.102556957
NIA Mouse Gene IndexU042185
EC3.1.13.-
PDB4PMW
Consensus CDS ProjectCCDS15124.1, CCDS48304.1
International Mouse Knockout Project StatusDis3l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048134 VEGA Gene Model | MGI Sequence Detail 346288 C57BL/6J ±  kb
transcript OTTMUST00000123633 VEGA | MGI Sequence Detail 3154 Not Applicable 
polypeptide OTTMUSP00000067456 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(981 from dbSNP Build 137)    SNPs within 2kb including multiple locations(983)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022966 Ribonuclease II/R, conserved site
Protein Ontology PR:000006493 DIS3-like exonuclease 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214591 Faehnle CR, et al., Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature. 2014 Oct 9;514(7521):252-6
All references(34)
Other
accession IDs
MGI:1924801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory