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Dis3l2
Gene Detail
 Symbol
Name
ID
Dis3l2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
MGI:2442555
Synonyms 4930429A22Rik, 8030493P09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
43.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:86703804-87050097 bp, + strand
From NCBI annotation of GRCm38

  346294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Dis3l2

Human
homologs
Human Homolog DIS3L2, DIS3 like 3'-5' exoribonuclease 2
NCBI Gene ID 129563
neXtProt AC  NX_Q8IYB7
Human Synonyms  FAM6A, hDIS3L2, PRLMNS
Human Chr (Location)  2q37.1; chr2:231961583-232343968 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DIS3L2
Alleles
and
phenotypes
All alleles(20) : Targeted(2) Gene trapped(18)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoplasmic mRNA processing body
Function 3'-5'-exoribonuclease activity, exonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (106)    Tissues (18)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 106
cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000053333 (Evidence)
Entrez Gene208718 (Evidence)
UniGene389152
DFCITC1577057, TC1590777, TC1594313, TC1613739, TC1617519, TC1624121
DoTSDT.101350638, DT.102556957, DT.110930953, DT.55128628, DT.55197990, DT.91349485, DT.94206251, DT.99848030, DT.99848031
NIA Mouse Gene IndexU042185
EC3.1.13.-
Consensus CDS ProjectCCDS15124.1, CCDS48304.1
International Mouse Knockout Project StatusDis3l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 208718 NCBI Gene Model | MGI Sequence Detail 346294 C57BL/6J ±  kb
transcript NM_001172157 RefSeq | MGI Sequence Detail 3171 C57BL/6 
polypeptide Q8CI75 UniProt | EBI | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(981 from dbSNP Build 137)    SNPs within 2kb including multiple locations(983)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR022966 Ribonuclease II/R, conserved site
Protein Ontology PR:000006493 DIS3-like exonuclease 2
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197683 Chang HM, et al., A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 9;497(7448):244-8
All references(31)
Other
accession IDs
MGI:1924801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory