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Kat6a Gene Detail
Summary
  • Symbol
    Kat6a
  • Name
    K(lysine) acetyltransferase 6A
  • Synonyms
    9930021N24Rik, MOZ, Myst3, Zfp220
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442415
    NCBI Gene: 244349
  • Gene Overview
    MyGene.info: KAT6A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22859535-22943259 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442415
protein coding gene Chr8:22859516-22943262 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033460
protein coding gene Chr8:20734961-20824396 (+)
A/J MGP_AJ_G0033440
protein coding gene Chr8:20056629-20141493 (+)
AKR/J MGP_AKRJ_G0033365
protein coding gene Chr8:20714947-20800050 (+)
BALB/cJ MGP_BALBcJ_G0033436
protein coding gene Chr8:20175895-20260666 (+)
C3H/HeJ MGP_C3HHeJ_G0033150
protein coding gene Chr8:20912847-21004362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033952
protein coding gene Chr8:21602192-21695130 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030904
protein coding gene Chr8:17390415-17474524 (+)
CAST/EiJ MGP_CASTEiJ_G0032476
protein coding gene Chr8:20328890-20419468 (+)
CBA/J MGP_CBAJ_G0033125
protein coding gene Chr8:22460836-22563498 (+)
DBA/2J MGP_DBA2J_G0033280
protein coding gene Chr8:20022526-20108933 (+)
FVB/NJ MGP_FVBNJ_G0033224
protein coding gene Chr8:19822843-19904648 (+)
LP/J MGP_LPJ_G0033369
protein coding gene Chr8:20723674-20814422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033267
protein coding gene Chr8:22051180-22139847 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033971
protein coding gene Chr8:20617864-20706141 (+)
PWK/PhJ MGP_PWKPhJ_G0032188
protein coding gene Chr8:19612216-19694612 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032021
protein coding gene Chr8:19986573-20070342 (+)
WSB/EiJ MGP_WSBEiJ_G0032592
protein coding gene Chr8:20819627-20909943 (+)



Homology
more
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MOZ, MRD32, MYST3, MYST-3, RUNXBP2, ZC2HC6A, ZNF220
  • Links
    NCBI Gene ID: 7994
    neXtProt AC: NX_Q92794
    UniProt: Q92794

  • Chr Location
    8p11.21; chr8:41929479-42052026 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Kat6a mouse models; 1 with human KAT6A associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 6 alleles in 10 genetic backgrounds
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal lethality, cyanosis, decreased hematopoietic progenitor cell numbers, and severely impaired spleen and thymus development, but are not anemic. Heterozygotes display strain background dependent reductions in fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031540 Ensembl Gene Model | MGI Sequence Detail 83725 C57BL/6J ±  kb
    transcript ENSMUST00000044331 Ensembl | MGI Sequence Detail 9113 Not Applicable  
    polypeptide ENSMUSP00000038181 Ensembl | MGI Sequence Detail 2003 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 128
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1926208
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
    • Latest
      J:266522 Elsen GE, et al., The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory