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Kat6a Gene Detail
Summary
  • Symbol
    Kat6a
  • Name
    K(lysine) acetyltransferase 6A
  • Synonyms
    9930021N24Rik, MOZ, Myst3, Zfp220
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442415
    NCBI Gene: 244349
  • Gene Overview
    MyGene.info: KAT6A
Location & Maps
more
  • Sequence Map
    Chr8:22859535-22943259 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83725 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MOZ, MRD32, MYST3, MYST-3, RUNXBP2, ZC2HC6A, ZNF220
  • Links
    NCBI Gene ID: 7994
    neXtProt AC: NX_Q92794

  • Chr Location
    8p11; chr8:41929479-42051989 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kat6a mouse models; 1 with human KAT6A associations

Human Disease Mouse Models
       DiGeorge Syndrome; DGS   OMIM: 188400 View 2 models
       Mental Retardation, Autosomal Dominant 32; MRD32   OMIM: 616268
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 4 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    5
  • Targeted
    9
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display perinatal lethality, cyanosis, decreased hematopoietic progenitor cell numbers, and severely impaired spleen and thymus development, but are not anemic. Heterozygotes display strain background dependent reductions in fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017302 VEGA Gene Model | MGI Sequence Detail 83725 C57BL/6J ±  kb
transcript OTTMUST00000041977 VEGA | MGI Sequence Detail 9041 Not Applicable  
polypeptide OTTMUSP00000018877 VEGA | MGI Sequence Detail 2003 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    cDNA 127
    Primer pair 6

    Microarray probesets 3
Other
Accession IDs
less
MGI:1926208
References
more
  • Summaries
    All 50
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 8
    Phenotypes 22
  • Earliest
    J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
  • Latest
    J:224155 You L, et al., The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet. 2015 Mar;11(3):e1005034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory