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Kat6a
Gene Detail
 Symbol
Name
ID
Kat6a
K(lysine) acetyltransferase 6A
MGI:2442415
Synonyms 9930021N24Rik, MOZ, Myst3, Zfp220
Feature Type protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:22859535-22943259 bp, + strand
From VEGA annotation of GRCm38

  83725 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kat6a

Human
homologs
Human Homolog KAT6A, K(lysine) acetyltransferase 6A
NCBI Gene ID 7994
neXtProt AC  NX_Q92794
Human Synonyms  MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220
Human Chr (Location)  8p11; chr8:41929479-42051988 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Targeted(6) Gene trapped(5)
 
Homozygous null mice display perinatal lethality, cyanosis, decreased hematopoietic progenitor cell numbers, and severely impaired spleen and thymus development, but are not anemic. Heterozygotes display strain background dependent reductions in fertility.
 
Human Diseases Modeled Using Mouse Kat6a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process aorta morphogenesis, cellular senescence, ...
Component Golgi apparatus, MOZ/MORF histone acetyltransferase complex, ...
Function acetyltransferase activity, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (110)    Tissues (41)    Images (7)
Theiler Stages: 2, 3, 17, 18, 20, 21, 22, 23
Assay TypeResults
RNA in situ 58
Western blot 7
RT-PCR 45
cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(133) cDNA(127) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017302 (Evidence)
Ensembl Gene ModelENSMUSG00000031540 (Evidence)
Entrez Gene244349 (Evidence)
UniGene182776
DFCITC1584307, TC1597212, TC1602927, TC1619796
DoTSDT.101255023, DT.101736587, DT.94173345
NIA Mouse Gene IndexU009177
EC2.3.1.48
Consensus CDS ProjectCCDS40294.1
International Mouse Knockout Project StatusKat6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017302 VEGA Gene Model | MGI Sequence Detail 83725 C57BL/6J ±  kb
transcript OTTMUST00000041976 VEGA | MGI Sequence Detail 9113 Not Applicable 
polypeptide OTTMUSP00000018876 VEGA | MGI Sequence Detail 2003 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR005818 Histone H1/H5
InterPro IPR002717 MOZ/SAS-like protein
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000010890 histone acetyltransferase MYST3
References (Earliest) J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
(Latest) J:188772 Voss AK, et al., MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
All references(43)
Other
accession IDs
MGI:1926208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory