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Brms1 Gene Detail
Summary
  • Symbol
    Brms1
  • Name
    breast cancer metastasis-suppressor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388804
    NCBI Gene: 107392
  • Gene Overview
    MyGene.info: BRMS1
Location & Maps
more
  • Sequence Map
    Chr19:5041404-5049917 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8514 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.23 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BRMS1, breast cancer metastasis suppressor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BRMS1, breast cancer metastasis suppressor 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 25855
    neXtProt AC: NX_Q9HCU9

  • Chr Location
    11q13.2; chr11:66337333-66345111 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    10
  • Targeted
    5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000080268 Ensembl Gene Model | MGI Sequence Detail 8514 C57BL/6J ±  kb
transcript ENSMUST00000116567 Ensembl | MGI Sequence Detail 1338 Not Applicable  
polypeptide ENSMUSP00000112266 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004817 breast cancer metastasis-suppressor 1
  • InterPro Domains
    IPR013907 Sds3-like
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
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MGI:2147665, MGI:2147748
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:73358 Hunter KW, et al., Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res. 2001 Dec 15;61(24):8866-72
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory