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Ppat
Gene Detail
Symbol

Name
ID
Ppat
phosphoribosyl pyrophosphate amidotransferase
MGI:2387203
Synonyms
5730454C12Rik, MGC:38417
Feature Type
protein coding gene
Genetic Map
Chromosome 5
41.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:76913249-76951578 bp, - strand
From VEGA annotation of GRCm38

  38330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPAT
Protein SuperFamily: Amd_phspho_trans
Gene Tree: Ppat

Human
homologs
PPAT, phosphoribosyl pyrophosphate amidotransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5471
neXtProt AC: NX_Q06203

Human Synonyms: ATASE, GPAT, PRAT

Human Chr (Location): 4q12; chr4:56393362-56435636 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ppat interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process glutamine catabolic process, protein homotetramerization, ...
Function amidophosphoribosyltransferase activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (202)    Tissues (104)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 202
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppat ; ZFIN ppat    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026529 (Evidence)
Ensembl Gene Model ENSMUSG00000029246 (Evidence)
Entrez Gene 231327 (Evidence)
DFCI TC1575948, TC1623105, TC1658311
NIA Mouse Gene Index U026328
EC 2.4.2.14
Consensus CDS Project CCDS51527.1
International Mouse Phenotyping Consortium Status Ppat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026529 VEGA Gene Model | MGI Sequence Detail 38330 C57BL/6J ±  kb
transcript OTTMUST00000065636 VEGA | MGI Sequence Detail 3981 Not Applicable 
polypeptide OTTMUSP00000032738 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(297 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005854 Amidophosphoribosyltransferase
InterPro IPR017932 Glutamine amidotransferase type 2 domain
InterPro IPR029055 Nucleophile aminohydrolases, N-terminal
InterPro IPR000836 Phosphoribosyltransferase domain
InterPro IPR029057 Phosphoribosyltransferase-like
Protein Ontology PR:000013061 amidophosphoribosyltransferase
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)
Other
accession IDs
MGI:1917832, MGI:2140739, MGI:2140788, MGI:2140930, MGI:2141313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory