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Pdlim2 Gene Detail
Summary
  • Symbol
    Pdlim2
  • Name
    PDZ and LIM domain 2
  • Synonyms
    4732462F18Rik, MGC:37634, mystique, SLIM
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384850
    NCBI Gene: 213019
  • Gene Overview
    MyGene.info: PDLIM2
Location & Maps
more
  • Sequence Map
    Chr14:70164218-70177681 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13464 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDLIM2, PDZ and LIM domain 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PDLIM2, PDZ and LIM domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYSTIQUE, SLIM
  • Links
    NCBI Gene ID: 64236
    neXtProt AC: NX_Q96JY6

  • Chr Location
    8p21.3; chr8:22578741-22598025 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Pdlim2
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    2
  • Tissues
    2
  • cDNA Data
    67
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033027 VEGA Gene Model | MGI Sequence Detail 13464 C57BL/6J ±  kb
transcript OTTMUST00000082413 VEGA | MGI Sequence Detail 1523 Not Applicable  
polypeptide OTTMUSP00000044168 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    93 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 67

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915048
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:150390 Yoshida K, et al., PKR-mediated degradation of STAT1 regulates osteoblast differentiation. Exp Cell Res. 2009 Jul 15;315(12):2105-14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory