Pdlim2 Gene Detail

Summary

• Symbol
  Pdlim2
• Name
  PDZ and LIM domain 2
• Synonyms
  4732462F18Rik, MGC:37634, mystique, SLIM

• Feature Type
  protein coding gene
• IDs
  MGI:2384850
  NCBI Gene: 213019
• Gene Overview
  MyGene.info: PDLIM2
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr14:70164218-70177681 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    13464 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 36.26 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  PDLIM2, PDZ and LIM domain 2

• Vertebrate Orthologs
  7

• Human Ortholog
  PDLIM2, PDZ and LIM domain 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  MYSTIQUE, SLIM
• Links
  HGNC:13992

  NCBI Gene ID: 64236

  neXtProt AC: NX_Q96JY6

  UniProt: Q96JY6

  
  
• Chr Location
  8p21.3; chr8:22578741-22598025 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 11006
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 zebrafish;1 macaque, rhesus
  
• HCOP
  human homology predictions: PDLIM2
• Protein SuperFamily
  PDZ and LIM domain protein
• Gene Tree
  Pdlim2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Gene trapped
  1
• Targeted
  1
• Genomic Mutations
  1 involving Pdlim2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  22 strains or lines available

Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  2

• External Resources
  FuncBase

Expression

• Assay Results
  2
• Tissues
  2
• cDNA Data
  67
• Literature Summary
  2

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase pdlim2
  ZFIN pdlim2

Interactions

• Pdlim2 interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...) View All

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  12
• UniProt
  5
• CCDS
  CCDS27248.1
• UniGene
  283968

• VEGA
  OTTMUSG00000033027 (Evidence)
• Ensembl
  ENSMUSG00000022090 (Evidence)
• NCBI Gene
  213019

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000033027	VEGA Gene Model | MGI Sequence Detail	13464	C57BL/6J
transcript	OTTMUST00000082413	VEGA | MGI Sequence Detail	1523	Not Applicable
polypeptide	OTTMUSP00000044168	VEGA | MGI Sequence Detail	349	Not Applicable

Polymorphisms

• SNPs within 2kb
  93 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000012509 PDZ and LIM domain protein 2
  (term hierarchy)
• PDB
  1VB7
• InterPro Domains
  IPR031847 Domain of unknown function DUF4749
  IPR001478 PDZ domain
  IPR036034 PDZ superfamily
  IPR001781 Zinc finger, LIM-type

Molecular
Reagents

• All nucleic 67

  cDNA 67

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:1915048

References

• Summaries
  All 32

  Developmental Gene Expression 2

  Gene Ontology 2

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:258150 Tanaka T, et al., HSP70 mediates degradation of the p65 subunit of nuclear factor kappaB to inhibit inflammatory signaling. Sci Signal. 2014 Dec 16;7(356):ra119