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Pdlim2
Gene Detail
Symbol

Name
ID
Pdlim2
PDZ and LIM domain 2
MGI:2384850
Synonyms
4732462F18Rik, MGC:37634, mystique, SLIM
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70164218-70177681 bp, - strand
From VEGA annotation of GRCm38

  13464 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: PDZ and LIM domain protein
Gene Tree: Pdlim2

Human
homologs
Human Homolog PDLIM2, PDZ and LIM domain 2 (mystique)
NCBI Gene ID 64236
neXtProt AC  NX_Q96JY6
Human Synonyms  MYSTIQUE, SLIM
Human Chr (Location)  8p21.3; chr8:22578741-22598025 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.
 
Interactions
Pdlim2 interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Component actin cytoskeleton, cortical actin cytoskeleton, ...
Function alpha-actinin binding, filamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033027 (Evidence)
Ensembl Gene ModelENSMUSG00000022090 (Evidence)
Entrez Gene213019 (Evidence)
UniGene283968
DFCITC1578144, TC1694810
DoTSDT.101367741, DT.94382832, DT.94269144, DT.94170020
NIA Mouse Gene IndexU035741
PDB1VB7
Consensus CDS ProjectCCDS27248.1
International Mouse Knockout Project StatusPdlim2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033027 VEGA Gene Model | MGI Sequence Detail 13464 C57BL/6J ±  kb
transcript OTTMUST00000082413 VEGA | MGI Sequence Detail 1523 Not Applicable 
polypeptide OTTMUSP00000044168 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(8)
Polymorphisms
SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000012509 PDZ and LIM domain protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:150390 Yoshida K, et al., PKR-mediated degradation of STAT1 regulates osteoblast differentiation. Exp Cell Res. 2009 Jul 15;315(12):2105-14
All references(34)
Other
accession IDs
MGI:1915048

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory