Pdlim2 MGI Mouse Gene Detail - MGI:2384850

Pdlim2 Gene Detail

Symbol

Pdlim2
Name

PDZ and LIM domain 2
Synonyms

4732462F18Rik, MGC:37634, mystique, SLIM

Feature Type

protein coding gene
IDs

MGI:2384850
NCBI Gene: 213019
Gene Overview

MyGene.info: PDLIM2
Alliance

gene page

Sequence Map

Chr14:70164218-70177681 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

13464 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.26 cM
Mapping Data

2 experiments

Human Ortholog

PDLIM2, PDZ and LIM domain 2

Vertebrate Orthologs

7

Human Ortholog

PDLIM2, PDZ and LIM domain 2
Orthology source: HomoloGene, HGNC
Synonyms

MYSTIQUE, SLIM
Links

HGNC:13992

NCBI Gene ID: 64236

neXtProt AC: NX_Q96JY6

UniProt: Q96JY6
Chr Location

8p21.3; chr8:22578741-22598025 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11006
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: PDLIM2
Protein SuperFamily

PDZ and LIM domain protein
Gene Tree

Pdlim2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Pdlim2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.

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All GO Annotations

10
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Assay Results

2
Tissues

2
cDNA Data

67
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pdlim2

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Pdlim2 interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

59
RefSeq

12
UniProt

5
CCDS

CCDS27248.1
UniGene

283968

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033027	VEGA Gene Model \| MGI Sequence Detail	13464	C57BL/6J	± kb
transcript	OTTMUST00000082413	VEGA \| MGI Sequence Detail	1523	Not Applicable
polypeptide	OTTMUSP00000044168	VEGA \| MGI Sequence Detail	349	Not Applicable

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SNPs within 2kb

93 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000012509 PDZ and LIM domain protein 2

(term hierarchy)
PDB

1VB7
InterPro Domains

IPR031847 Domain of unknown function DUF4749

IPR001478 PDZ domain

IPR001781 Zinc finger, LIM-type

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All nucleic 67

cDNA 67

Microarray probesets 2

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MGI:1915048

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:150390 Yoshida K, et al., PKR-mediated degradation of STAT1 regulates osteoblast differentiation. Exp Cell Res. 2009 Jul 15;315(12):2105-14

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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