Pdlim2
Gene Detail

Symbol

Name
ID

Pdlim2
PDZ and LIM domain 2
MGI:2384850

Synonyms

4732462F18Rik, MGC:37634, mystique, SLIM

Feature Type

protein coding gene

Genetic Map

Chromosome 14
36.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:70164218-70177681 bp, - strand From VEGA annotation of GRCm38   13464 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:11006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: PDZ and LIM domain protein
Gene Tree: Pdlim2

Human
homologs

Human Homolog		PDLIM2, PDZ and LIM domain 2 (mystique)
NCBI Gene ID		64236
neXtProt AC		NX_Q96JY6
Human Synonyms		MYSTIQUE, SLIM
Human Chr (Location)		8p21.3; chr8:22578741-22598025 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.

 

Interactions

Pdlim2 interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Component	actin cytoskeleton, cortical actin cytoskeleton, ...
Function	alpha-actinin binding, filamin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	2

cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(67) cDNA(67)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000033027 (Evidence)
Ensembl Gene Model	ENSMUSG00000022090 (Evidence)
Entrez Gene	213019 (Evidence)
UniGene	283968
DFCI	TC1578144, TC1694810
DoTS	DT.94382832, DT.94170020, DT.101367741, DT.94269144
NIA Mouse Gene Index	U035741
PDB	1VB7
Consensus CDS Project	CCDS27248.1
International Mouse Knockout Project Status	Pdlim2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033027	VEGA Gene Model | MGI Sequence Detail	13464	C57BL/6J
transcript	OTTMUST00000082413	VEGA | MGI Sequence Detail	1523	Not Applicable
polypeptide	OTTMUSP00000044168	VEGA | MGI Sequence Detail	349	Not Applicable

All sequences(66) RefSeq(12) UniProt(5)

Polymorphisms

SNPs within 2kb(94 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000012509	PDZ and LIM domain protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:150390 Yoshida K, et al., PKR-mediated degradation of STAT1 regulates osteoblast differentiation. Exp Cell Res. 2009 Jul 15;315(12):2105-14
All references(34)

Other
accession IDs

MGI:1915048