About   Help   FAQ
Pdlim2 Gene Detail
Summary
  • Symbol
    Pdlim2
  • Name
    PDZ and LIM domain 2
  • Synonyms
    4732462F18Rik, MGC:37634, mystique, SLIM
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384850
    NCBI Gene: 213019
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70401667-70415130 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384850
protein coding gene Chr14:70401667-70415140 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021532
protein coding gene Chr14:64787156-64802796 (-)
A/J MGP_AJ_G0021491
protein coding gene Chr14:63428407-63440736 (-)
AKR/J MGP_AKRJ_G0021467
protein coding gene Chr14:65329289-65343476 (-)
BALB/cJ MGP_BALBcJ_G0021497
protein coding gene Chr14:63188741-63201199 (-)
C3H/HeJ MGP_C3HHeJ_G0021274
protein coding gene Chr14:65041315-65054618 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021936
protein coding gene Chr14:67704893-67719262 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019476
protein coding gene Chr14:61264856-61277820 (-)
CAST/EiJ MGP_CASTEiJ_G0020791
protein coding gene Chr14:61624095-61637795 (-)
CBA/J MGP_CBAJ_G0021241
protein coding gene Chr14:69819852-69835954 (-)
DBA/2J MGP_DBA2J_G0021364
protein coding gene Chr14:62809873-62822627 (-)
FVB/NJ MGP_FVBNJ_G0021343
protein coding gene Chr14:62237292-62250407 (-)
LP/J MGP_LPJ_G0021435
protein coding gene Chr14:66038391-66055897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021372
protein coding gene Chr14:68734796-68748631 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021960
protein coding gene Chr14:64592740-64606054 (-)
PWK/PhJ MGP_PWKPhJ_G0020535
protein coding gene Chr14:59571640-59584560 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020368
protein coding gene Chr14:60517085-60532643 (-)
WSB/EiJ MGP_WSBEiJ_G0020844
protein coding gene Chr14:64895705-64909662 (-)



Homology
more
  • Human Ortholog
    PDLIM2, PDZ and LIM domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDLIM2, PDZ and LIM domain 2
  • Synonyms
    MYSTIQUE, SLIM
  • Links
    NCBI Gene ID: 64236
    neXtProt AC: NX_Q96JY6
    UniProt: Q96JY6

  • Chr Location
    8p21.3; chr8:22578279-22598026 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display increased IFN-gamma production by Th1 cells and an enhanced inflammatory response to in vivo challenge with heat-killed Listeria monocytogenes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022090 Ensembl Gene Model | MGI Sequence Detail 13464 C57BL/6J ±  kb
transcript ENSMUST00000022681 Ensembl | MGI Sequence Detail 1523 Not Applicable  
polypeptide ENSMUSP00000022681 Ensembl | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 68
    cDNA 68

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915048
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:305911 Li L, et al., PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 Mar 8;6(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory