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cir Gene Detail
Summary
  • Symbol
    cir
  • Name
    circling
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:2176711
    NCBI Gene: 191577
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:108641085-111021636 bp
  • From MGI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, Syntenic
  • Mapping Data
    2 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes are deaf, hyperactive, and exhibit circling behavior, reduced rearing behavior, and reduced body weight. Outer hair cells are absent and spiral ganglion cells show severe degeneration. Females exhibit pup cannibalization.
Gene Ontology
(GO)
Classifications
less
Expression
less
  • Other Vertebrate Links
    Xenbase cir1
Sequences &
Gene Models
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References
more
  • Summaries
    All 11
    Phenotypes 10
  • Earliest
    J:73719 Lee JW, et al., Circling mouse: possible animal model for deafness. Comp Med. 2001 Dec;51(6):550-4
  • Latest
    J:218768 Lee Y, et al., Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice. Neurosci Lett. 2015 Jan 1;584:320-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/12/2020
MGI 6.15
The Jackson Laboratory