Rims1
Gene Detail

Symbol Name ID

Rims1 regulating synaptic membrane exocytosis 1 MGI:2152971

Synonyms

C030033M19Rik, RIM1, RIM1a, RIM1alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 1

8.54 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:22288422-22805724 bp, - strand From NCBI annotation of GRCm38   517303 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rims1

Human homologs

Human Homolog		RIMS1, regulating synaptic membrane exocytosis 1
NCBI Gene ID		22999
neXtProt AC		NX_Q86UR5
Human Synonyms		CORD7, RAB3IP2, RIM, RIM1
Human Chr (Location)		6q12-q13; chr6:71886703-72403143 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human RIMS1

Mutations, alleles, and phenotypes

All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.

 

Interactions

Rims1 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component	cell, cell junction, ...
Function	ion channel binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (23)    Tissues (23)    Images (2)
Theiler Stages: 23, 27

Assay Type	Results
RNA in situ	23

cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000041670 (Evidence)
Entrez Gene	116837 (Evidence)
DFCI	TC1584249, TC1602006, TC1602752, TC1602960, TC1603274, TC1607487, TC1608740
DoTS	DT.101231808, DT.101342697, DT.101360233, DT.103585729, DT.110910407, DT.110910421, DT.110910483, DT.55261661, DT.91328128
NIA Mouse Gene Index	U021170
International Mouse Knockout Project Status	Rims1

Sequences

Length	Strain/Species
genomic	116837	NCBI Gene Model | MGI Sequence Detail	517303	C57BL/6J
transcript	NM_053270	RefSeq | MGI Sequence Detail	4392	Not Specified
polypeptide	Q99NE5	UniProt | EBI | MGI Sequence Detail	1463	Not Applicable

All sequences(70) RefSeq(10) UniProt(9)

Polymorphisms

SNPs within 2kb(3752 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3754)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR001478	PDZ domain
InterPro	IPR010911	Rab-binding domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000014009	regulating synaptic membrane exocytosis protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:187680 Pitsch J, et al., The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus. J Neurosci. 2012 Sep 5;32(36):12384-95
All references(66)

Other accession IDs

MGI:1924723