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Rims1
Gene Detail
Symbol

Name
ID
Rims1
regulating synaptic membrane exocytosis 1
MGI:2152971
Synonyms
C030033M19Rik, RIM1, RIM1a, RIM1alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 1
8.54 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:22288422-22805724 bp, - strand
From VEGA annotation of GRCm38

  517303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RIMS1
Gene Tree: Rims1

Human
homologs
RIMS1, regulating synaptic membrane exocytosis 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 22999
neXtProt AC: NX_Q86UR5

Human Synonyms: CORD7, RAB3IP2, RIM, RIM1

Human Chr (Location): 6q12-q13; chr6:71886703-72403143 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RIMS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
 
Interactions
Rims1 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component cell, cell junction, ...
Function ion channel binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (21)    Tissues (21)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rims1    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000046025 (Evidence)
Ensembl Gene Model ENSMUSG00000041670 (Evidence)
Entrez Gene 116837 (Evidence)
DFCI TC1602006, TC1602752, TC1602960, TC1608740, TC1607487, TC1603274, TC1584249
DoTS DT.101360233, DT.101342697, DT.103585729, DT.101231808, DT.110910407, DT.91328128, DT.110910421, DT.55261661, DT.110910483
NIA Mouse Gene Index U021170
International Mouse Phenotyping Consortium Status Rims1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046025 VEGA Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
transcript OTTMUST00000120204 VEGA | MGI Sequence Detail 2411 Not Applicable 
polypeptide OTTMUSP00000066642 VEGA | MGI Sequence Detail 803 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(10) UniProt(11)
Polymorphisms
SNPs within 2kb(3752 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3754)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR010911 Rab-binding domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000014009 regulating synaptic membrane exocytosis protein 1
References
(Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:217830 Lacoste B, et al., Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron. 2014 Sep 3;83(5):1117-30
All references(67)
Other
accession IDs
MGI:1924723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory