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Rims1
Gene Detail
Symbol

Name
ID
Rims1
regulating synaptic membrane exocytosis 1
MGI:2152971
Synonyms
C030033M19Rik, RIM1, RIM1a, RIM1alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 1
8.54 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:22288422-22805724 bp, - strand
From VEGA annotation of GRCm38

  517303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rims1

Human
homologs
Human Homolog RIMS1, regulating synaptic membrane exocytosis 1
NCBI Gene ID 22999
neXtProt AC  NX_Q86UR5
Human Synonyms  CORD7, RAB3IP2, RIM, RIM1
Human Chr (Location)  6q12-q13; chr6:71886703-72403143 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RIMS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
 
Interactions
Rims1 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component cell, cell junction, ...
Function ion channel binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (23)    Tissues (23)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046025 VEGA Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
transcript OTTMUST00000120204 VEGA | MGI Sequence Detail 2411 Not Applicable 
polypeptide OTTMUSP00000066642 VEGA | MGI Sequence Detail 803 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(10) UniProt(18)
Polymorphisms
SNPs within 2kb(3752 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3754)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR010911 Rab-binding domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000014009 regulating synaptic membrane exocytosis protein 1
References
(Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:187680 Pitsch J, et al., The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus. J Neurosci. 2012 Sep 5;32(36):12384-95
All references(67)
Other
accession IDs
MGI:1924723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory