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Rims1 Gene Detail
Summary
  • Symbol
    Rims1
  • Name
    regulating synaptic membrane exocytosis 1
  • Synonyms
    C030033M19Rik, RIM1, RIM1a, RIM1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152971
    NCBI Gene: 116837
  • Gene Overview
    MyGene.info: RIMS1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:22288422-22805724 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      517303 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 8.54 cM, cytoband A5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CORD7, RAB3IP2, RIM, RIM1
  • Links
    NCBI Gene ID: 22999
    neXtProt AC: NX_Q86UR5
    UniProt: Q86UR5

  • Chr Location
    6q13; chr6:71886703-72403143 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 128399
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RIMS1
  • Gene Tree
    Rims1
Human Diseases
more
  • Diseases
    1 with human RIMS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    46
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    21
  • Tissues
    21
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
      66
    • RefSeq
      10
    • UniProt
      12
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046025 VEGA Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
    transcript OTTMUST00000120204 VEGA | MGI Sequence Detail 2411 Not Applicable  
    polypeptide OTTMUSP00000066642 VEGA | MGI Sequence Detail 803 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3729 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924723
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 6
      Gene Ontology 18
      Phenotypes 34
    • Earliest
      J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
    • Latest
      J:260426 de Jong APH, et al., RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018 Mar 29;None(None):None
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory