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Rims1 Gene Detail
Summary
  • Symbol
    Rims1
  • Name
    regulating synaptic membrane exocytosis 1
  • Synonyms
    C030033M19Rik, RIM1, RIM1a, RIM1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152971
    NCBI Gene: 116837
  • Gene Overview
    MyGene.info: RIMS1
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:22288422-22805724 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 8.54 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3729 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152971
 protein coding gene Chr1:22286251-22805994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015882
 protein coding gene Chr1:20024269-20557947 (-)
A/J MGP_AJ_G0015863
 protein coding gene Chr1:19704015-20200198 (-)
AKR/J MGP_AKRJ_G0015820
 protein coding gene Chr1:19831397-20359431 (-)
BALB/cJ MGP_BALBcJ_G0015819
 protein coding gene Chr1:19433053-19934591 (-)
C3H/HeJ MGP_C3HHeJ_G0015653
 protein coding gene Chr1:19859741-20372596 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016273
 protein coding gene Chr1:20963297-21509988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013992
 protein coding gene Chr1:17851823-18340739 (-)
CAST/EiJ MGP_CASTEiJ_G0015232
 protein coding gene Chr1:19954864-20499828 (-)
CBA/J MGP_CBAJ_G0015625
 protein coding gene Chr1:21464033-22041469 (-)
DBA/2J MGP_DBA2J_G0015724
 protein coding gene Chr1:19205241-19706830 (-)
FVB/NJ MGP_FVBNJ_G0015728
 protein coding gene Chr1:18982553-19478909 (-)
LP/J MGP_LPJ_G0015796
 protein coding gene Chr1:20247186-20761028 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015748
 protein coding gene Chr1:22441075-23010386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016320
 protein coding gene Chr1:19773877-20303507 (-)
PWK/PhJ MGP_PWKPhJ_G0015015
 protein coding gene Chr1:18981424-19476678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014796
 protein coding gene Chr1:19860999-20368979 (-)
WSB/EiJ MGP_WSBEiJ_G0015295
 protein coding gene Chr1:19737729-20250478 (-)



Homology
more
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CORD7, RAB3IP2, RIM, RIM1
  • Links
    NCBI Gene ID: 22999
    neXtProt AC: NX_Q86UR5
    UniProt: Q86UR5

  • Chr Location
    6q13; chr6:71886703-72403143 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 128399
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RIMS1
  • Gene Tree
    Rims1
Human Diseases
more
  • Diseases
    1 with human RIMS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    21
  • Tissues
    21
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
      78
    • RefSeq
      10
    • UniProt
      12
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116837 NCBI Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
    transcript NM_053270 RefSeq | MGI Sequence Detail 7121 C57BL/6  
    polypeptide Q99NE5 UniProt | EBI | MGI Sequence Detail 1463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924723
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 7
      Gene Ontology 21
      Phenotypes 39
    • Earliest
      J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
    • Latest
      J:268178 Liu C, et al., Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018 Feb 8;172(4):706-718.e15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory