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Rims1
Gene Detail
 Symbol
Name
ID
Rims1
regulating synaptic membrane exocytosis 1
MGI:2152971
Synonyms C030033M19Rik, RIM1, RIM1a, RIM1alpha
Feature Type protein coding gene
Genetic Map
Chromosome 1
8.54 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:22288422-22805724 bp, - strand
From NCBI annotation of GRCm38

  517303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rims1

Human
homologs
Human Homolog RIMS1, regulating synaptic membrane exocytosis 1
NCBI Gene ID 22999
neXtProt AC  NX_Q86UR5
Human Synonyms  CORD7, RAB3IP2, RIM, RIM1
Human Chr (Location)  6q12-q13; chr6:71886703-72403143 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RIMS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
 
Interactions
Rims1 interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component cell, cell junction, ...
Function ion channel binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (23)    Tissues (23)    Images (2)
Theiler Stages: 23, 27
Assay TypeResults
RNA in situ 23
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000041670 (Evidence)
Entrez Gene116837 (Evidence)
DFCITC1584249, TC1602006, TC1602752, TC1602960, TC1603274, TC1607487, TC1608740
DoTSDT.101231808, DT.101342697, DT.101360233, DT.103585729, DT.110910407, DT.110910421, DT.110910483, DT.55261661, DT.91328128
NIA Mouse Gene IndexU021170
International Mouse Knockout Project StatusRims1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 116837 NCBI Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
transcript NM_053270 RefSeq | MGI Sequence Detail 4392 Not Specified 
polypeptide Q99NE5 UniProt | EBI | MGI Sequence Detail 1463 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(10) UniProt(9)
Polymorphisms SNPs within 2kb(3752 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3754)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR010911 Rab-binding domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000014009 regulating synaptic membrane exocytosis protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:187680 Pitsch J, et al., The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus. J Neurosci. 2012 Sep 5;32(36):12384-95
All references(66)
Other
accession IDs
MGI:1924723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory