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Rims1 Gene Detail
Summary
  • Symbol
    Rims1
  • Name
    regulating synaptic membrane exocytosis 1
  • Synonyms
    C030033M19Rik, RIM1, RIM1a, RIM1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152971
    NCBI Gene: 116837
  • Gene Overview
    MyGene.info: RIMS1
Location & Maps
more
  • Sequence Map
    Chr1:22288422-22805724 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      517303 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 8.54 cM, cytoband A5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CORD7, RAB3IP2, RIM, RIM1
  • Links
    NCBI Gene ID: 22999
    neXtProt AC: NX_Q86UR5

  • Chr Location
    6q12-q13; chr6:71886703-72403143 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 128399
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RIMS1
  • Gene Tree
    Rims1
Human Diseases
more
  • Diseases
    1 with human RIMS1 associations

Human Disease Mouse Models
       Cone-Rod Dystrophy 7; CORD7   OMIM: 603649
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    4
  • Genomic Mutations
    1 involving Rims1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    21
  • Tissues
    21
  • cDNA Data
    6
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
    63
  • RefSeq
    10
  • UniProt
    11
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046025 VEGA Gene Model | MGI Sequence Detail 517303 C57BL/6J ±  kb
transcript OTTMUST00000120204 VEGA | MGI Sequence Detail 2411 Not Applicable  
polypeptide OTTMUSP00000066642 VEGA | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3729 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924723
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 16
    Phenotypes 28
  • Earliest
    J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
  • Latest
    J:226477 Grabner CP, et al., RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors. J Neurosci. 2015 Sep 23;35(38):13133-47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory