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C1galt1
Gene Detail
Symbol

Name
ID
C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
MGI:2151071
Synonyms
2210410E06Rik, core 1 beta3-Gal-T, T-synthase
Feature Type
protein coding gene
Genetic Map
Chromosome 6
3.37 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:7844842-7872047 bp, + strand
From VEGA annotation of GRCm38

  27206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10599  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: C1GALT1
Gene Tree: C1galt1

Human
homologs
C1GALT1, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 56913
neXtProt AC: NX_Q9NS00

Human Synonyms: C1GALT, T-synthase

Human Chr (Location): 7p21.3; chr7:7182547-7248651 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null allele show impaired angiogenesis, chaotic microvascular networks in brain, and fatal hemorrhage by E14. Eggs homozygous for another null allele show a slightly thinner zona pellucida. Mice homozygous for an ENU-induced allele develop thrombocytopenia and renal disease.
 
Phenotype Images(4)
Interactions
C1galt1 interacts with 184 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (217)    Tissues (107)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 217
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c1galt1    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023144 (Evidence)
Ensembl Gene Model ENSMUSG00000042460 (Evidence)
Entrez Gene 94192 (Evidence)
DFCI TC1602347, TC1584214, TC1635736
DoTS DT.486633, DT.101325928
NIA Mouse Gene Index U006531
EC 2.4.1.122
Consensus CDS Project CCDS19908.1
International Mouse Phenotyping Consortium Status C1galt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023144 VEGA Gene Model | MGI Sequence Detail 27206 C57BL/6J ±  kb
transcript OTTMUST00000055938 VEGA | MGI Sequence Detail 2452 Not Applicable 
polypeptide OTTMUSP00000026842 VEGA | MGI Sequence Detail 363 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(194 from dbSNP Build 137)    SNPs within 2kb including multiple locations(202)
Protein-related
information
ResourceIDDescription
InterPro IPR026842 C1GALT1
InterPro IPR003378 Fringe-like
Protein Ontology PR:000004873 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218520 Grasa P, et al., Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression. FASEB J. 2015 Feb;29(2):525-39
All references(47)
Other
accession IDs
MGI:1917425, MGI:2141630

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory