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Smap1 Gene Detail
Summary
  • Symbol
    Smap1
  • Name
    small ArfGAP 1
  • Synonyms
    1700056O10Rik, 4921514B13Rik, 4921525H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138261
    NCBI Gene: 98366
  • Gene Overview
    MyGene.info: SMAP1
Location & Maps
more
  • Sequence Map
    Chr1:23844846-23922317 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77472 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 9.79 cM, cytoband A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SMAP1, small ArfGAP 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMAP1, small ArfGAP 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SMAP-1
  • Links
    NCBI Gene ID: 60682
    neXtProt AC: NX_Q8IYB5

  • Chr Location
    6q13; chr6:70667771-70862015 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 134676
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SMAP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    6 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    6
  • Genomic Mutations
    1 involving Smap1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit perturbed receptor trafficking and myelodysplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026521 VEGA Gene Model | MGI Sequence Detail 77472 C57BL/6J ±  kb
transcript OTTMUST00000065602 VEGA | MGI Sequence Detail 2289 Not Applicable  
polypeptide OTTMUSP00000032714 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    483 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015258 stromal membrane-associated protein 1
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
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MGI:1918153, MGI:1918155, MGI:1920661
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:79308 Sato Y, et al., Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. J Biochem. 1998 Jul;124(1):209-16
  • Latest
    J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory