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Smap1 Gene Detail
Summary
  • Symbol
    Smap1
  • Name
    small ArfGAP 1
  • Synonyms
    1700056O10Rik, 4921514B13Rik, 4921525H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138261
    NCBI Gene: 98366
  • Gene Overview
    MyGene.info: SMAP1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:23844846-23922317 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 9.79 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    483 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138261
protein coding gene Chr1:23844825-23922450 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015886
protein coding gene Chr1:21673676-21745613 (-)
A/J MGP_AJ_G0015867
protein coding gene Chr1:21243551-21314912 (-)
AKR/J MGP_AKRJ_G0015824
protein coding gene Chr1:21458603-21540862 (-)
BALB/cJ MGP_BALBcJ_G0015823
protein coding gene Chr1:20982181-21061585 (-)
C3H/HeJ MGP_C3HHeJ_G0015657
protein coding gene Chr1:21465093-21542398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016277
protein coding gene Chr1:22640479-22714501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013996
protein coding gene Chr1:19322274-19398779 (-)
CAST/EiJ MGP_CASTEiJ_G0015236
protein coding gene Chr1:21574457-21652701 (-)
CBA/J MGP_CBAJ_G0015629
protein coding gene Chr1:23187583-23267948 (-)
DBA/2J MGP_DBA2J_G0015728
protein coding gene Chr1:20729016-20809169 (-)
FVB/NJ MGP_FVBNJ_G0015732
protein coding gene Chr1:20498942-20569394 (-)
LP/J MGP_LPJ_G0015800
protein coding gene Chr1:21872717-21951467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015752
protein coding gene Chr1:24205256-24283093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016324
protein coding gene Chr1:21355443-21432851 (-)
PWK/PhJ MGP_PWKPhJ_G0015019
protein coding gene Chr1:20492674-20567455 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014800
protein coding gene Chr1:21472353-21552572 (-)
WSB/EiJ MGP_WSBEiJ_G0015299
protein coding gene Chr1:21301725-21375791 (-)



Homology
more
  • Human Ortholog
    SMAP1, small ArfGAP 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMAP1, small ArfGAP 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMAP-1
  • Links
    NCBI Gene ID: 60682
    neXtProt AC: NX_Q8IYB5
    UniProt: Q8IYB5

  • Chr Location
    6q13; chr6:70667771-70862015 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 134676
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMAP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    6 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit perturbed receptor trafficking and myelodysplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026155 Ensembl Gene Model | MGI Sequence Detail 77472 C57BL/6J ±  kb
    transcript ENSMUST00000027339 Ensembl | MGI Sequence Detail 2289 Not Applicable  
    polypeptide ENSMUSP00000027339 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918153, MGI:1918155, MGI:1920661
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:79308 Sato Y, et al., Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. J Biochem. 1998 Jul;124(1):209-16
    • Latest
      J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory