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B3gnt5 Gene Detail
Summary
  • Symbol
    B3gnt5
  • Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137302
    NCBI Gene: 108105
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:19760234-19772760 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.23 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137302
protein coding gene Chr16:19760208-19772760 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022633
protein coding gene Chr16:17037666-17049983 (+)
A/J MGP_AJ_G0022595
protein coding gene Chr16:16234356-16247014 (+)
AKR/J MGP_AKRJ_G0022570
protein coding gene Chr16:16881796-16894336 (+)
BALB/cJ MGP_BALBcJ_G0022599
protein coding gene Chr16:16384842-16397366 (+)
C3H/HeJ MGP_C3HHeJ_G0022364
protein coding gene Chr16:17019971-17032520 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023050
protein coding gene Chr16:17369686-17382230 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020567
protein coding gene Chr16:16955555-16968205 (+)
CAST/EiJ MGP_CASTEiJ_G0021894
protein coding gene Chr16:17000431-17012884 (+)
CBA/J MGP_CBAJ_G0022336
protein coding gene Chr16:18099354-18111943 (+)
DBA/2J MGP_DBA2J_G0022468
protein coding gene Chr16:16136231-16148729 (+)
FVB/NJ MGP_FVBNJ_G0022443
protein coding gene Chr16:16204721-16217282 (+)
LP/J MGP_LPJ_G0022535
protein coding gene Chr16:16805640-16818259 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022463
protein coding gene Chr16:17790829-17803337 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023061
protein coding gene Chr16:16810998-16823534 (+)
PWK/PhJ MGP_PWKPhJ_G0021635
protein coding gene Chr16:16406385-16419214 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021464
protein coding gene Chr16:16619218-16631546 (+)
WSB/EiJ MGP_WSBEiJ_G0021938
protein coding gene Chr16:16814621-16828416 (+)



Homology
more
  • Human Ortholog
    B3GNT5, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    B3GNT5, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B3GN-T5, beta3Gn-T5
  • Links
    NCBI Gene ID: 84002
    neXtProt AC: NX_Q9BYG0
    UniProt: Q9BYG0

  • Chr Location
    3q27.1; chr3:183253207-183273391 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 24989
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: B3GNT5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice may show variable types of lethality or no lethality depending on the allele. Mice homozygous for 3 alleles show B cell abnormalities. Mice homozygous or heterozygous for 2 allele show reduced fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108105 NCBI Gene Model | MGI Sequence Detail 12527 C57BL/6J ±  kb
    transcript NM_001159407 RefSeq | MGI Sequence Detail 4872 C57BL/6  
    polypeptide Q8BGY6 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 74
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:70124 Togayachi A, et al., Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. J Biol Chem. 2001 Jun 22;276(25):22032-40
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory