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Arid1a Gene Detail
Summary
  • Symbol
    Arid1a
  • Name
    AT rich interactive domain 1A (SWI-like)
  • Synonyms
    1110030E03Rik, BAF250a, Osa1, Smarcf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935147
    NCBI Gene: 93760
  • Gene Overview
    MyGene.info: ARID1A
Location & Maps
more
  • Sequence Map
    Chr4:133679008-133756769 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77762 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B120, BAF250, BAF250a, BM029, C1orf4, ELD, hELD, hOSA1, MRD14, OSA1, P270, SMARCF1
  • Links
    NCBI Gene ID: 8289
    neXtProt AC: NX_O14497

  • Chr Location
    1p35.3; chr1:26696031-26782110 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ARID1A associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 14; MRD14   OMIM: 614607
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    190
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Gene trapped
    176
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    4 involving Arid1a
  • Incidental Mutations
Embryos with homozygous null alleles arrest development at E6.5 with failure to form a mesoderm layer. Mice homozygous for an allele lacking exon 2 and 3 die shortly after birth and exhibit an increase in the hematopoietic stem cell population of the fetal liver at E14.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011035 VEGA Gene Model | MGI Sequence Detail 77762 C57BL/6J ±  kb
transcript OTTMUST00000025856 VEGA | MGI Sequence Detail 8187 Not Applicable  
polypeptide OTTMUSP00000011856 VEGA | MGI Sequence Detail 2287 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    422 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004262 AT-rich interactive domain-containing protein 1A
  • InterPro Domains
    IPR001606 ARID DNA-binding domain
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR030094 SWI/SNF-like complex subunit BAF250a
    IPR021906 SWI/SNF-like complex subunit BAF250/Osa
Molecular
Reagents
less
  • All nucleic 247
    cDNA 244
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:1915989
References
more
  • Summaries
    All 53
    Developmental Gene Expression 13
    Gene Ontology 12
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:227728 Zhai Y, et al., Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival. J Pathol. 2015 Aug 17;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory