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Arid1a
Gene Detail
 Symbol
Name
ID
Arid1a
AT rich interactive domain 1A (SWI-like)
MGI:1935147
Synonyms 1110030E03Rik, BAF250a, Osa1, Smarcf1
Feature Type protein coding gene
Genetic Map
Chromosome 4
66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:133679008-133756769 bp, - strand
From VEGA annotation of GRCm38

  77762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arid1a

Human
homologs
Human Homolog ARID1A, AT rich interactive domain 1A (SWI-like)
NCBI Gene ID 8289
neXtProt AC  NX_O14497
Human Synonyms  B120, BAF250, BAF250a, BM029, C1orf4, ELD, hELD, hOSA1, MRD14, OSA1, P270, SMARCF1
Human Chr (Location)  1p35.3; chr1:26696031-26782110 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARID1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(185) : Chemically induced (ENU)(2) Gene trapped(176) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos with homozygous null alleles arrest development at E6.5 with failure to form a mesoderm layer. Mice homozygous for an allele lacking exon 2 and 3 die shortly after birth and exhibit an increase in the hematopoietic stem cell population of the fetal liver at E14.5.
 
Interactions
Arid1a interacts with 359 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process androgen receptor signaling pathway, ATP-dependent chromatin remodeling, ...
Component BAF-type complex, intracellular, ...
Function DNA binding, ligand-dependent nuclear receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (256)    Tissues (168)    Images (38)
Theiler Stages: 2, 3, 4, 5, 16, 17, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 237
Western blot 4
RT-PCR 15
cDNA source data(243)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(247) cDNA(244) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000011035 (Evidence)
Ensembl Gene ModelENSMUSG00000007880 (Evidence)
Entrez Gene93760 (Evidence)
UniGene22478
DFCITC1574032
DoTSDT.110786482, DT.492125
Consensus CDS ProjectCCDS38908.1
International Mouse Knockout Project StatusArid1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011035 VEGA Gene Model | MGI Sequence Detail 77762 C57BL/6J ±  kb
transcript OTTMUST00000025856 VEGA | MGI Sequence Detail 8187 Not Applicable 
polypeptide OTTMUSP00000011856 VEGA | MGI Sequence Detail 2287 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021906 Protein of unknown function DUF3518
Protein Ontology PR:000004262 AT-rich interactive domain-containing protein 1A
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:199644 Staahl BT, et al., Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013 Jun 19;33(25):10348-61
All references(52)
Other
accession IDs
MGI:1915989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory