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Arid1a Gene Detail
Summary
  • Symbol
    Arid1a
  • Name
    AT rich interactive domain 1A (SWI-like)
  • Synonyms
    1110030E03Rik, BAF250a, Osa1, Smarcf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935147
    NCBI Gene: 93760
  • Gene Overview
    MyGene.info: ARID1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:133679008-133756769 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARID1A, AT-rich interaction domain 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, hELD, hOSA1, MRD14, OSA1, P270, SMARCF1
  • Links
    NCBI Gene ID: 8289
    neXtProt AC: NX_O14497
    UniProt: O14497

  • Chr Location
    1p36.11; chr1:26696031-26782110 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21216
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ARID1A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Arid1a mouse models; 1 with human ARID1A associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos with homozygous null alleles arrest development at E6.5 with failure to form a mesoderm layer. Mice homozygous for an allele lacking exon 2 and 3 die shortly after birth and exhibit an increase in the hematopoietic stem cell population of the fetal liver at E14.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000011035 VEGA Gene Model | MGI Sequence Detail 77762 C57BL/6J ±  kb
    transcript OTTMUST00000025856 VEGA | MGI Sequence Detail 8187 Not Applicable  
    polypeptide OTTMUSP00000011856 VEGA | MGI Sequence Detail 2287 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      422 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001606 ARID DNA-binding domain
      IPR036431 ARID DNA-binding domain superfamily
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR030094 SWI/SNF-like complex subunit BAF250a
      IPR033388 SWI/SNF-like complex subunit BAF250, C-terminal
      IPR021906 SWI/SNF-like complex subunit BAF250/Osa
    Molecular
    Reagents
    less
    • All nucleic 249
      cDNA 245
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915989
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 15
      Phenotypes 27
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:259945 Mathur R, et al., ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb;49(2):296-302

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory