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Nme4 Gene Detail
Summary
  • Symbol
    Nme4
  • Name
    NME/NM23 nucleoside diphosphate kinase 4
  • Synonyms
    2610027N22Rik, 2810024O08Rik, 5730493H09Rik, NM23-M4, non-metastatic cells 4, protein expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931148
    NCBI Gene: 56520
  • Gene Overview
    MyGene.info: NME4
Location & Maps
more
  • Sequence Map
    Chr17:26091734-26095508 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3775 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NDPK-D, nm23-H4, NM23H4
  • Links
    NCBI Gene ID: 4833
    neXtProt AC: NX_O00746

  • Chr Location
    16p13.3; chr16:396755-400754 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    111
  • Gene trapped
    107
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Nme4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026500 VEGA Gene Model | MGI Sequence Detail 3775 C57BL/6J ±  kb
transcript OTTMUST00000065527 VEGA | MGI Sequence Detail 912 Not Applicable  
polypeptide OTTMUSP00000032669 VEGA | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011284 nucleoside diphosphate kinase, mitochondrial
  • EC
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR023005 Nucleoside diphosphate kinase, active site
Molecular
Reagents
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  • All nucleic 38
    cDNA 35
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917197, MGI:1917868, MGI:1922663
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory