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Nme4
Gene Detail
Symbol

Name
ID
Nme4
NME/NM23 nucleoside diphosphate kinase 4
MGI:1931148
Synonyms
2610027N22Rik, 2810024O08Rik, 5730493H09Rik, NM23-M4, non-metastatic cells 4, protein expressed in
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.06 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:26091734-26095508 bp, - strand
From VEGA annotation of GRCm38

  3775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NME4
Protein SuperFamily: nucleoside diphosphate kinase
Gene Tree: Nme4

Human
homologs
NME4, NME/NM23 nucleoside diphosphate kinase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4833
neXtProt AC: NX_O00746

Human Synonyms: NDPK-D, nm23-H4, NM23H4

Human Chr (Location): 16p13.3; chr16:396755-400754 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(111) : Gene trapped(107) Radiation induced(2) Targeted(2)
Genomic Mutations involving Nme4 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Nme4 interacts with 58 markers (Mir16-2, Mir98, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process CTP biosynthetic process, GTP biosynthetic process, ...
Component cytosol, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (143)    Tissues (135)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
RT-PCR 2
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nme4 ; ZFIN nme4    NEW 
Molecular
reagents
All nucleic(38) cDNA(35) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026500 (Evidence)
Ensembl Gene Model ENSMUSG00000024177 (Evidence)
Entrez Gene 56520 (Evidence)
UniGene 41787
DFCI TC1578885, TC1593169
DoTS DT.491287, DT.91340614
NIA Mouse Gene Index U037575
EC 2.7.4.6
Consensus CDS Project CCDS28544.1
International Mouse Phenotyping Consortium Status Nme4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026500 VEGA Gene Model | MGI Sequence Detail 3775 C57BL/6J ±  kb
transcript OTTMUST00000065527 VEGA | MGI Sequence Detail 912 Not Applicable 
polypeptide OTTMUSP00000032669 VEGA | MGI Sequence Detail 186 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001564 Nucleoside diphosphate kinase
InterPro IPR023005 Nucleoside diphosphate kinase, active site
Protein Ontology PR:000011284 nucleoside diphosphate kinase, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916
All references(45)
Other
accession IDs
MGI:1917197, MGI:1917868, MGI:1922663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory