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Nme4 Gene Detail
Summary
  • Symbol
    Nme4
  • Name
    NME/NM23 nucleoside diphosphate kinase 4
  • Synonyms
    2610027N22Rik, 2810024O08Rik, 5730493H09Rik, NM23-M4, non-metastatic cells 4, protein expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931148
    NCBI Gene: 56520
  • Gene Overview
    MyGene.info: NME4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26091734-26095508 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931148
protein coding gene Chr17:26091734-26095519 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023389
protein coding gene Chr17:25221079-25224838 (-)
A/J MGP_AJ_G0023348
protein coding gene Chr17:24479060-24482826 (-)
AKR/J MGP_AKRJ_G0023314
protein coding gene Chr17:24587542-24594016 (-)
BALB/cJ MGP_BALBcJ_G0023353
protein coding gene Chr17:24701552-24705323 (-)
C3H/HeJ MGP_C3HHeJ_G0023113
protein coding gene Chr17:24977373-24982242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023795
protein coding gene Chr17:26286174-26290081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021271
protein coding gene Chr17:21931110-21935083 (-)
CAST/EiJ MGP_CASTEiJ_G0022615
protein coding gene Chr17:24873324-24877075 (-)
CBA/J MGP_CBAJ_G0023088
protein coding gene Chr17:27215674-27223508 (-)
DBA/2J MGP_DBA2J_G0023218
protein coding gene Chr17:24073554-24078527 (-)
FVB/NJ MGP_FVBNJ_G0023188
protein coding gene Chr17:23831016-23835828 (-)
LP/J MGP_LPJ_G0023295
protein coding gene Chr17:25509625-25513392 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023207
protein coding gene Chr17:26786366-26791453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023835
protein coding gene Chr17:24919770-24923542 (-)
PWK/PhJ MGP_PWKPhJ_G0022364
protein coding gene Chr17:22843319-22847261 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022182
protein coding gene Chr17:22998190-23001965 (-)
WSB/EiJ MGP_WSBEiJ_G0022678
protein coding gene Chr17:24959730-24964001 (-)



Homology
more
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NDPK-D, nm23-H4, NM23H4
  • Links
    NCBI Gene ID: 4833
    neXtProt AC: NX_O00746
    UniProt: O00746

  • Chr Location
    16p13.3; chr16:396755-400754 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024177 Ensembl Gene Model | MGI Sequence Detail 3775 C57BL/6J ±  kb
transcript ENSMUST00000025007 Ensembl | MGI Sequence Detail 912 Not Applicable  
polypeptide ENSMUSP00000025007 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR023005 Nucleoside diphosphate kinase, active site
    IPR034907 Nucleoside diphosphate kinase-like domain
    IPR036850 Nucleoside diphosphate kinase-like domain superfamily
Molecular
Reagents
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  • All nucleic 40
    cDNA 36
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1917197, MGI:1917868, MGI:1922663
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory