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Diap3
Gene Detail
Symbol

Name
ID
Diap3
diaphanous homolog 3 (Drosophila)
MGI:1927222
Synonyms
4930417P13Rik, Drf3, mDia2, p134MDia2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
43.95 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:86656323-87141251 bp, - strand
From NCBI annotation of GRCm38

  484929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Diap3

Human
homologs
Human Homolog DIAPH3, diaphanous-related formin 3
NCBI Gene ID 81624
neXtProt AC  NX_Q9NSV4
Human Synonyms  AN, AUNA1, DIA2, diap3, DRF3, mDia2, NSDAN
Human Chr (Location)  13q21.2; chr13:59665583-60163985 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DIAPH3
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(23) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display embryonic mortality and abnormal cytokinesis of RBC.
 
Interactions
Diap3 interacts with 261 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process actin cytoskeleton organization, cellular component organization
Component cytoplasm, nucleus
Function actin binding, Rho GTPase binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (13)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 79
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022021 (Evidence)
Entrez Gene56419 (Evidence)
UniGene440585
DFCITC1582021, TC1651227, TC1615777
DoTSDT.55281693, DT.487272, DT.97385046, DT.110775527, DT.97410715, DT.110775512
NIA Mouse Gene IndexU035818
Consensus CDS ProjectCCDS36990.1
International Mouse Knockout Project StatusDiap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56419 NCBI Gene Model | MGI Sequence Detail 484929 C57BL/6J ±  kb
transcript NM_019670 RefSeq | MGI Sequence Detail 3516 Not Specified 
polypeptide Q9Z207 UniProt | EBI | MGI Sequence Detail 1171 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(19)
Polymorphisms
SNPs within 2kb(5341 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5355)
Protein-related
information
ResourceIDDescription
InterPro IPR015425 Actin-binding FH2
InterPro IPR016024 Armadillo-type fold
InterPro IPR014767 Diaphanous autoregulatory
InterPro IPR010472 Diaphanous FH3
InterPro IPR010473 Diaphanous GTPase-binding
InterPro IPR010465 DRF autoregulatory
InterPro IPR014768 GTPase-binding/formin homology 3
Protein Ontology PR:000006477 protein diaphanous homolog 3
Graphical View of Protein Domain Structure
References
(Earliest) J:46957 Alberts AS, et al., Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22
(Latest) J:205519 Watanabe S, et al., Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013 Nov 27;5(4):926-32
All references(52)
Other
accession IDs
MGI:1914650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory