Diap3
Gene Detail

Symbol Name ID

Diap3 diaphanous homolog 3 (Drosophila) MGI:1927222

Synonyms

4930417P13Rik, Drf3, mDia2, p134MDia2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

43.95 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:86656323-87141114 bp, - strand From NCBI annotation of GRCm38   484792 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Diap3

Human homologs

Human Homolog		DIAPH3, diaphanous homolog 3 (Drosophila)
NCBI Gene ID		81624
neXtProt AC		NX_Q9NSV4
Human Synonyms		AN, AUNA1, DIA2, diap3, DRF3, mDia2, NSDAN
Human Chr (Location)		13q21.2; chr13:60239717-60738119 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DIAPH3

Alleles and phenotypes

All alleles(27) : Targeted(4) Gene trapped(23)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	actin cytoskeleton organization, cellular component organization
Component	cytoplasm, nucleus
Function	actin binding, Rho GTPase binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (79)    Tissues (13)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	79

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) cDNA(53)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022021 (Evidence)
Entrez Gene	56419 (Evidence)
UniGene	440585
DFCI	TC1582021, TC1615777, TC1651227
DoTS	DT.110775512, DT.110775527, DT.487272, DT.55281693, DT.97385046, DT.97410715
NIA Mouse Gene Index	U035818
Consensus CDS Project	CCDS36990.1
International Mouse Knockout Project Status	Diap3

Sequences

Length	Strain/Species
genomic	56419	NCBI Gene Model | MGI Sequence Detail	484792	C57BL/6J
transcript	NM_019670	RefSeq | MGI Sequence Detail	3516	Not Specified
polypeptide	Q9Z207	UniProt | EBI | MGI Sequence Detail	1171	Not Applicable

All sequences(43) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(2810 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015425	Actin-binding FH2
InterPro	IPR003104	Actin-binding FH2/DRF autoregulatory
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR014767	Diaphanous autoregulatory
InterPro	IPR010472	Diaphanous FH3
InterPro	IPR010473	Diaphanous GTPase-binding
InterPro	IPR010465	DRF autoregulatory
InterPro	IPR014768	GTPase-binding/formin homology 3
Protein Ontology	PR:000006477	protein diaphanous 3

Graphical View of Protein Domain Structure

References

(Earliest) J:46957 Alberts AS, et al., Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(49)

Other accession IDs

MGI:1914650