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Ascc3
Gene Detail
Symbol

Name
ID
Ascc3
activating signal cointegrator 1 complex subunit 3
MGI:1925237
Synonyms
ASC1p200, B630009I04Rik, Helic1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
24.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:50592669-50851202 bp, + strand
From Ensembl annotation of GRCm38

  258534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ASCC3
Gene Tree: Ascc3

Human
homologs
ASCC3, activating signal cointegrator 1 complex subunit 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10973
neXtProt AC: NX_Q8N3C0

Human Synonyms: ASC1p200, HELIC1, RNAH

Human Chr (Location): 6q16; chr6:100508194-100881372 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ascc3 interacts with 225 markers (Mir15b, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell proliferation, cellular response to DNA damage stimulus, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, ATP-dependent 3'-5' DNA helicase activity, ...
External Resources: FuncBase
Expression
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100127710    NEW 
Molecular
reagents
All nucleic(58) cDNA(58)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000038774 (Evidence)
Entrez Gene 77987 (Evidence)
UniGene 222497
DFCI TC1606927, TC1603375, TC1582699
DoTS DT.94222719, DT.40176271
NIA Mouse Gene Index U011495, U364131, U365919
EC 3.6.4.12
Consensus CDS Project CCDS48555.1
International Mouse Phenotyping Consortium Status Ascc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038774 Ensembl Gene Model | MGI Sequence Detail 258534 C57BL/6J ±  kb
transcript ENSMUST00000035606 Ensembl | MGI Sequence Detail 7477 Not Applicable 
polypeptide ENSMUSP00000036726 Ensembl | MGI Sequence Detail 2198 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(1196 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR004179 Sec63 domain
Protein Ontology PR:000004361 activating signal cointegrator 1 complex subunit 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
All references(28)
Other
accession IDs
MGI:3039633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory