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Prune1 Gene Detail
Summary
  • Symbol
    Prune1
  • Name
    prune exopolyphosphatase
  • Synonyms
    9230112O05Rik, Prune, Prune-M1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925152
    NCBI Gene: 229589
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95253674-95282076 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925152
protein coding gene Chr3:95253674-95282076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027579
protein coding gene Chr3:95967945-95999743 (-)
A/J MGP_AJ_G0027538
protein coding gene Chr3:92995840-93023867 (-)
AKR/J MGP_AKRJ_G0027505
protein coding gene Chr3:95145495-95174491 (-)
BALB/cJ MGP_BALBcJ_G0027550
protein coding gene Chr3:92773693-92802167 (-)
C3H/HeJ MGP_C3HHeJ_G0027283
protein coding gene Chr3:95428011-95457834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027998
protein coding gene Chr3:99527522-99561825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025338
protein coding gene Chr3:89358320-89388107 (-)
CAST/EiJ MGP_CASTEiJ_G0026733
protein coding gene Chr3:94714317-94746648 (-)
CBA/J MGP_CBAJ_G0027260
protein coding gene Chr3:103141836-103174348 (-)
DBA/2J MGP_DBA2J_G0027399
protein coding gene Chr3:92287951-92316218 (-)
FVB/NJ MGP_FVBNJ_G0027370
protein coding gene Chr3:90363006-90391548 (-)
LP/J MGP_LPJ_G0027508
protein coding gene Chr3:97268507-97301682 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027397
protein coding gene Chr3:109253041-109283892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028052
protein coding gene Chr3:94799074-94829624 (-)
PWK/PhJ MGP_PWKPhJ_G0026461
protein coding gene Chr3:92168544-92196643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026282
protein coding gene Chr3:93095738-93127328 (-)
WSB/EiJ MGP_WSBEiJ_G0026815
protein coding gene Chr3:95185396-95217791 (-)



Homology
more
  • Human Ortholog
    PRUNE1, prune exopolyphosphatase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRUNE1, prune exopolyphosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRES17, DRES-17, H-PRUNE, HTCD37, NMIHBA, PRUNE
  • Links
    NCBI Gene ID: 58497
    neXtProt AC: NX_Q86TP1
    UniProt: Q86TP1

  • Chr Location
    1q21.3; chr1:151008391-151035713 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit a flattened pancake appearance at E9.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 229589 NCBI Gene Model | MGI Sequence Detail 28403 C57BL/6J ±  kb
transcript NM_173347 RefSeq | MGI Sequence Detail 3160 C57BL/6  
polypeptide Q8BIW1 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 5
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory