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Elp4
Gene Detail
Symbol

Name
ID
Elp4
elongation protein 4 homolog (S. cerevisiae)
MGI:1925016
Synonyms
A330107A17Rik, Paxneb
Feature Type
protein coding gene
Genetic Map
Chromosome 2
55.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:105701027-105904564 bp, - strand
From VEGA annotation of GRCm38

  203538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32433  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ELP4
Protein SuperFamily: RNA polymerase II elongator complex protein 4
Gene Tree: Elp4

Human
homologs
ELP4, elongator acetyltransferase complex subunit 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26610
neXtProt AC: NX_Q96EB1

Human Synonyms: AN, C11orf19, dJ68P15A.1, hELP4, PAX6NEB, PAXNEB

Human Chr (Location): 11p13; chr11:31509729-31785252 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ELP4

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Spontaneous(2) Targeted(2)
Genomic Mutations involving Elp4 (2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Elp4 interacts with 445 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process histone H3 acetylation, histone H4 acetylation, ...
Component cytoplasm, Elongator holoenzyme complex, ...
Function histone acetyltransferase activity, phosphorylase kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 2
Northern blot 1
Western blot 2
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase elp4 ; ZFIN elp4    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015120 (Evidence)
Ensembl Gene Model ENSMUSG00000027167 (Evidence)
Entrez Gene 77766 (Evidence)
DFCI TC1576326, TC1635771
Consensus CDS Project CCDS16500.1
International Mouse Phenotyping Consortium Status Elp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015120 VEGA Gene Model | MGI Sequence Detail 203538 C57BL/6J ±  kb
transcript OTTMUST00000035858 VEGA | MGI Sequence Detail 3048 Not Applicable 
polypeptide OTTMUSP00000016086 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(636 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008728 Elongator complex protein 4
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000007045 elongator complex protein 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory