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Nln Gene Detail
Summary
  • Symbol
    Nln
  • Name
    neurolysin (metallopeptidase M3 family)
  • Synonyms
    4930472G13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923055
    NCBI Gene: 75805
  • Gene Overview
    MyGene.info: NLN
Location & Maps
more
  • Sequence Map
    Chr13:104023439-104109614 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86176 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 56.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NLN, neurolysin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NLN, neurolysin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGTBP, EP24.16, MEP, MOP
  • Links
    NCBI Gene ID: 57486
    neXtProt AC: NX_Q9BYT8

  • Chr Location
    5q12.3; chr5:65722196-65829283 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased glucose tolerance, insulin sensitivity, and gluconeogensis. Mice also show decreased body weight and run less in a low intensity regime to exhaustion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021710 Ensembl Gene Model | MGI Sequence Detail 86176 C57BL/6J ±  kb
transcript ENSMUST00000109315 Ensembl | MGI Sequence Detail 3780 Not Applicable  
polypeptide ENSMUSP00000104938 Ensembl | MGI Sequence Detail 704 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1050 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 88
    cDNA 88

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145509
References
more
  • Summaries
    All 38
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:223275 Speth RC, et al., Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PLoS One. 2014;9(8):e105762

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory