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Prss59 Gene Detail
Summary
  • Symbol
    Prss59
  • Name
    protease, serine 59
  • Synonyms
    1700074P13Rik, Tryx5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920731
    NCBI Gene: 73481
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:40897371-40917491 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 18.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920731
protein coding gene Chr6:40897371-40917975 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030619
protein coding gene Chr6:39389482-39410713 (-)
A/J MGP_AJ_G0030592
protein coding gene Chr6:37670904-37691801 (-)
AKR/J MGP_AKRJ_G0030519
protein coding gene Chr6:38877514-38898404 (-)
BALB/cJ MGP_BALBcJ_G0030602
protein coding gene Chr6:37888202-37907717 (-)
C3H/HeJ MGP_C3HHeJ_G0030315
protein coding gene Chr6:38883641-38903563 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031056
protein coding gene Chr6:40384208-40404247 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028268
protein coding gene Chr6:35501567-35523762 (-)
CAST/EiJ MGP_CASTEiJ_G0029717
protein coding gene Chr6:38801733-38820791 (-)
CBA/J MGP_CBAJ_G0030293
protein coding gene Chr6:42013763-42033770 (-)
DBA/2J MGP_DBA2J_G0030437
protein coding gene Chr6:37488729-37509312 (-)
FVB/NJ MGP_FVBNJ_G0030391
protein coding gene Chr6:37259393-37279509 (-)
LP/J MGP_LPJ_G0030524
protein coding gene Chr6:39410897-39432870 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030427
protein coding gene Chr6:44248188-44267966 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031086
protein coding gene Chr6:38825641-38849381 (-)
PWK/PhJ MGP_PWKPhJ_G0029431
protein coding gene Chr6:37138770-37159521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029267
protein coding gene Chr6:38564852-38585446 (-)
WSB/EiJ MGP_WSBEiJ_G0029793
protein coding gene Chr6:38779017-38799234 (-)



Homology
more
  • Human Ortholog
    PRSS59P, serine protease 59, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS59P, serine protease 59, pseudogene
  • Synonyms
    TRY2P, Tryx5
  • Links
    NCBI Gene ID: 207147

  • Chr Location
    7q34; chr7:142268284-142272249 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show male infertility due to impaired sperm migration from the uterus into the oviduct.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029883 Ensembl Gene Model | MGI Sequence Detail 20121 C57BL/6J ±  kb
    transcript ENSMUST00000122181 Ensembl | MGI Sequence Detail 1542 Not Applicable  
    polypeptide ENSMUSP00000112987 Ensembl | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141612
    References
    more
    • Summaries
      All 25
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:303285 Zhang H, et al., Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct. J Cell Physiol. 2020 Sep;235(9):6058-6072

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/22/2022
    MGI 6.21
    The Jackson Laboratory