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Ndufv2 Gene Detail
Summary
  • Symbol
    Ndufv2
  • Name
    NADH dehydrogenase (ubiquinone) flavoprotein 2
  • Synonyms
    2900010C23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920150
    NCBI Gene: 72900
  • Gene Overview
    MyGene.info: NDUFV2
Location & Maps
more
  • Sequence Map
    Chr17:66078795-66101559 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22765 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 35.26 cM, cytoband E1.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDUFV2, NADH:ubiquinone oxidoreductase core subunit V2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NDUFV2, NADH:ubiquinone oxidoreductase core subunit V2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-24k
  • Links
    NCBI Gene ID: 4729
    neXtProt AC: NX_P19404

  • Chr Location
    18p11.22; chr18:9102630-9134345 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFV2 associations

Human Disease Mouse Models
       Mitochondrial Complex I Deficiency   OMIM: 252010
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    58
  • Gene trapped
    55
  • Targeted
    2
  • Transposon induced
    1
  • Incidental Mutations
Mice homozygous for a transposon induced allele may exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016284 VEGA Gene Model | MGI Sequence Detail 22765 C57BL/6J ±  kb
transcript OTTMUST00000039096 VEGA | MGI Sequence Detail 1540 Not Applicable  
polypeptide OTTMUSP00000017460 VEGA | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011105 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
  • EC
  • InterPro Domains
    IPR002023 NADH-quinone oxidoreductase subunit E-like
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 7
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229102 Chen T, et al., NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition. Brain Res. 2015 Nov 2;1625:102-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory