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Trim32
Gene Detail
 Symbol
Name
ID
Trim32
tripartite motif-containing 32
MGI:1917057
Synonyms 1810045E12Rik, 3f3, BBS11, Zfp117
Feature Type protein coding gene
Genetic Map
Chromosome 4
34.43 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:65604986-65616238 bp, + strand
From VEGA annotation of GRCm38

  11253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trim32

Human
homologs
Human Homolog TRIM32, tripartite motif containing 32
NCBI Gene ID 22954
neXtProt AC  NX_Q13049
Human Synonyms  BBS11, HT2A, LGMD2H, TATIP
Human Chr (Location)  9q33.1; chr9:116687302-116701300 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TRIM32
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a knock-out allele exhibit impaired adult muscle regeneration and myopathy.
 
Human Diseases Modeled Using Mouse Trim32 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Trim32 interacts with 174 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process innate immune response, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, ...
Component cytoplasm, intracellular, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (13)    Tissues (13)    Images (2)
Theiler Stages: 17, 23
Assay TypeResults
RNA in situ 13
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(6) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000317 (Evidence)
Ensembl Gene ModelENSMUSG00000051675 (Evidence)
Entrez Gene69807 (Evidence)
UniGene22786
DFCITC1575514
DoTSDT.483907
NIA Mouse Gene IndexU042539
EC6.3.2.-
Consensus CDS ProjectCCDS18270.1
International Mouse Knockout Project StatusTrim32
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000317 VEGA Gene Model | MGI Sequence Detail 11253 C57BL/6J ±  kb
transcript OTTMUST00000000822 VEGA | MGI Sequence Detail 3194 Not Applicable 
polypeptide OTTMUSP00000000377 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR027370 RING-type zinc-finger, LisH dimerisation motif
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016654 E3 ubiquitin-protein ligase TRIM32
References (Earliest) J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
(Latest) J:212980 Cohen S, et al., Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation. J Cell Biol. 2014 Mar 3;204(5):747-58
All references(52)
Disease annotation references (3)
Other
accession IDs
MGI:1341837, MGI:1341880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory