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Trim32
Gene Detail
Symbol

Name
ID
Trim32
tripartite motif-containing 32
MGI:1917057
Synonyms
1810045E12Rik, 3f3, BBS11, Zfp117
Feature Type
protein coding gene
Genetic Map
Chromosome 4
34.43 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:65604986-65616238 bp, + strand
From VEGA annotation of GRCm38

  11253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRIM32
Gene Tree: Trim32

Human
homologs
TRIM32, tripartite motif containing 32
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 22954
neXtProt AC: NX_Q13049

Human Synonyms: BBS11, HT2A, LGMD2H, TATIP

Human Chr (Location): 9q33.1; chr9:116687302-116701300 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRIM32

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a knock-out allele exhibit impaired adult muscle regeneration and myopathy.
 
Human Diseases Modeled in Mice Using Trim32 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Trim32 interacts with 173 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (13)    Tissues (13)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trim32 ; ZFIN trim32    NEW 
Molecular
reagents
All nucleic(58) Genomic(6) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000317 (Evidence)
Ensembl Gene Model ENSMUSG00000051675 (Evidence)
Entrez Gene 69807 (Evidence)
UniGene 22786
DFCI TC1575514
DoTS DT.483907
NIA Mouse Gene Index U042539
EC 6.3.2.-
Consensus CDS Project CCDS18270.1
International Mouse Phenotyping Consortium Status Trim32
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000317 VEGA Gene Model | MGI Sequence Detail 11253 C57BL/6J ±  kb
transcript OTTMUST00000000822 VEGA | MGI Sequence Detail 3194 Not Applicable 
polypeptide OTTMUSP00000000377 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000315 B-box-type zinc finger
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR027370 RING-type zinc-finger, LisH dimerisation motif
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016654 E3 ubiquitin-protein ligase TRIM32
References
(Earliest) J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
(Latest) J:221144 Mokhonova EI, et al., The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2. Hum Mol Genet. 2015 May 15;24(10):2873-83
All references(52)
Disease annotation references (3)
Other
accession IDs
MGI:1341837, MGI:1341880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory