Trim32
Gene Detail

Symbol Name ID

Trim32 tripartite motif-containing 32 MGI:1917057

Synonyms

1810045E12Rik, 3f3, BBS11, Zfp117

Feature Type

protein coding gene

Genetic Map

Chromosome 4

34.43 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:65604986-65616238 bp, + strand From VEGA annotation of GRCm38   11253 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Trim32

Human homologs

Human Homolog		TRIM32, tripartite motif containing 32
NCBI Gene ID		22954
neXtProt AC		NX_Q13049
Human Synonyms		BBS11, HT2A, LGMD2H, TATIP
Human Chr (Location)		9q33.1; chr9:119449581-119463579 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TRIM32

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a knock-out allele exhibit impaired adult muscle regeneration and myopathy.

 
Human Diseases Modeled Using Mouse Trim32 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	negative regulation of apoptotic process, positive regulation of cell cycle, ...
Component	cytoplasm, intracellular, ...
Function	ligase activity, metal ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (13)    Tissues (13)    Images (2)
Theiler Stages: 17, 23

Assay Type	Results
RNA in situ	13

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(6) cDNA(51)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000317 (Evidence)
Ensembl Gene Model	ENSMUSG00000051675 (Evidence)
Entrez Gene	69807 (Evidence)
UniGene	22786
DFCI	TC1575514
DoTS	DT.483907
NIA Mouse Gene Index	U042539
EC	6.3.2.-
Consensus CDS Project	CCDS18270.1
International Mouse Knockout Project Status	Trim32

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000317	VEGA Gene Model | MGI Sequence Detail	11253	C57BL/6J
transcript	OTTMUST00000000822	VEGA | MGI Sequence Detail	3194	Not Applicable
polypeptide	OTTMUSP00000000377	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(47) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(67 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001258	NHL repeat
InterPro	IPR013017	NHL repeat, subgroup
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000016654	tripartite motif-containing protein 32

References

(Earliest) J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
(Latest) J:190749 Cohen S, et al., Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. J Cell Biol. 2012 Aug 20;198(4):575-89
All references(50)

Other accession IDs

MGI:1341837, MGI:1341880