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Smco2 Gene Detail
Summary
  • Symbol
    Smco2
  • Name
    single-pass membrane protein with coiled-coil domains 2
  • Synonyms
    1700023A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916621
    NCBI Gene: 69371
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:146850110-146871404 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.70 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    376 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916621
protein coding gene Chr6:146850104-146871406 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031492
protein coding gene Chr6:151881491-151909137 (+)
A/J MGP_AJ_G0031467
protein coding gene Chr6:145859379-145881790 (+)
AKR/J MGP_AKRJ_G0031395
protein coding gene Chr6:150197906-150220534 (+)
BALB/cJ MGP_BALBcJ_G0031475
protein coding gene Chr6:145611740-145640496 (+)
C3H/HeJ MGP_C3HHeJ_G0031196
protein coding gene Chr6:150247506-150269134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031936
protein coding gene Chr6:155926974-155949430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029060
protein coding gene Chr6:144598369-144621150 (+)
CAST/EiJ MGP_CASTEiJ_G0030565
protein coding gene Chr6:149886352-149908854 (+)
CBA/J MGP_CBAJ_G0031156
protein coding gene Chr6:161880619-161911426 (+)
DBA/2J MGP_DBA2J_G0031312
protein coding gene Chr6:144637917-144659483 (+)
FVB/NJ MGP_FVBNJ_G0031264
protein coding gene Chr6:143379732-143403103 (+)
LP/J MGP_LPJ_G0031398
protein coding gene Chr6:151961994-151987927 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031304
protein coding gene Chr6:165603201-165629996 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031969
protein coding gene Chr6:150019680-150042320 (+)
PWK/PhJ MGP_PWKPhJ_G0030291
protein coding gene Chr6:143161686-143183323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030115
protein coding gene Chr6:148169514-148194396 (+)
WSB/EiJ MGP_WSBEiJ_G0030658
protein coding gene Chr6:150638496-150661573 (+)



Homology
more
  • Human Ortholog
    SMCO2, single-pass membrane protein with coiled-coil domains 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SMCO2, single-pass membrane protein with coiled-coil domains 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C12orf70
  • Links
    NCBI Gene ID: 341346
    neXtProt AC: NX_A6NFE2
    UniProt: A6NFE2

  • Chr Location
    12p11.23; chr12:27446482-27506911 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and display normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69371 NCBI Gene Model | MGI Sequence Detail 21295 C57BL/6J ±  kb
    transcript NM_027059 RefSeq | MGI Sequence Detail 1268 C57BL/6  
    polypeptide Q9DA21 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR026617 Transmembrane and coiled-coil domain-containing protein 2/5
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/20/2020
    MGI 6.16
    The Jackson Laboratory