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Sec14l2
Gene Detail
Symbol

Name
ID
Sec14l2
SEC14-like 2 (S. cerevisiae)
MGI:1915065
Synonyms
1300013M05Rik, Spf, tap
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.87 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:4097039-4123415 bp, - strand
From VEGA annotation of GRCm38

  26377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Sec14l2

Human
homologs
Human Homolog SEC14L2, SEC14-like 2 (S. cerevisiae)
NCBI Gene ID 23541
neXtProt AC  NX_O76054
Human Synonyms  C22orf6, SPF, TAP, TAP1
Human Chr (Location)  22q12.2; chr22:30396941-30425303 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased cholesterol synthesis and plasma levels under fasting conditions compared to wild-type mice.
 
Interactions
Sec14l2 interacts with 190 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process positive regulation of catalytic activity, positive regulation of cholesterol biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function enzyme activator activity, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) Genomic(1) cDNA(74)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005050 (Evidence)
Ensembl Gene ModelENSMUSG00000003585 (Evidence)
Entrez Gene67815 (Evidence)
UniGene253922
DFCITC1580689
DoTSDT.492637
NIA Mouse Gene IndexU032444
Consensus CDS ProjectCCDS24377.1
International Mouse Knockout Project StatusSec14l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005050 VEGA Gene Model | MGI Sequence Detail 26377 C57BL/6J ±  kb
transcript OTTMUST00000011245 VEGA | MGI Sequence Detail 2631 Not Applicable 
polypeptide OTTMUSP00000005243 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR011074 CRAL/TRIO, N-terminal domain
InterPro IPR009038 GOLD
Protein Ontology PR:000014577 SEC14-like protein 2
References
(Earliest) J:113817 Caras IW, et al., Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. J Biol Chem. 1980 Apr 25;255(8):3575-80
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory