Rpe MGI Mouse Gene Detail - MGI:1913896 - ribulose-5-phosphate-3-epimerase

Symbol

Rpe
Name

ribulose-5-phosphate-3-epimerase
Synonyms

2810429B02Rik, 5730518J08Rik

Feature Type

protein coding gene
IDs

MGI:1913896
NCBI Gene: 66646
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:66739990-66758964 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 33.61 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

171 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913896	protein coding gene	Chr1:66739957-66758964 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016114	protein coding gene	Chr1:66962778-66981785 (+)
A/J	MGP_AJ_G0016097	protein coding gene	Chr1:64592442-64611038 (+)
AKR/J	MGP_AKRJ_G0016054	protein coding gene	Chr1:66438281-66456932 (+)
BALB/cJ	MGP_BALBcJ_G0016052	protein coding gene	Chr1:64666896-64685071 (+)
C3H/HeJ	MGP_C3HHeJ_G0015883	protein coding gene	Chr1:66688985-66707881 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016505	protein coding gene	Chr1:69547283-69565032 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014226	protein coding gene	Chr1:60528072-60545041 (+)
CAST/EiJ	MGP_CASTEiJ_G0015467	protein coding gene	Chr1:65923982-65944018 (+)
CBA/J	MGP_CBAJ_G0015856	protein coding gene	Chr1:71791239-71815749 (+)
DBA/2J	MGP_DBA2J_G0015957	protein coding gene	Chr1:63983103-64001541 (+)
FVB/NJ	MGP_FVBNJ_G0015960	protein coding gene	Chr1:63235922-63253496 (+)
LP/J	MGP_LPJ_G0016029	protein coding gene	Chr1:67905168-67926466 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015980	protein coding gene	Chr1:74761320-74793599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016552	protein coding gene	Chr1:66390946-66411071 (+)
PWK/PhJ	MGP_PWKPhJ_G0015254	protein coding gene	Chr1:63377227-63396323 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015033	protein coding gene	Chr1:65852718-65870127 (+)
WSB/EiJ	MGP_WSBEiJ_G0015529	protein coding gene	Chr1:66117452-66135400 (+)

Human Ortholog

RPE, ribulose-5-phosphate-3-epimerase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPE, ribulose-5-phosphate-3-epimerase
Synonyms

RPE2-1
Links

HGNC:10293

NCBI Gene ID: 6120

neXtProt AC: NX_Q96AT9

UniProt: Q96AT9
Chr Location

2q34; chr2:210002565-210022260 (+) GRCh38

Human Ortholog

RPEL1, ribulose-5-phosphate-3-epimerase like 1
Links

HGNC:45241

NCBI Gene ID: 729020

neXtProt AC: NX_Q2QD12

UniProt: Q2QD12
Chr Location

10q24.33; chr10:103245887-103248016 (+) GRCh38

MGI Vertebrate Homology

Rpe stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPE, RPEL1
Protein SuperFamily

RPE
Gene Tree

Rpe

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Rpe
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpe

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All Sequences

75
RefSeq

16
UniProt

8
CCDS

CCDS15022.1, CCDS78602.1

Ensembl

ENSMUSG00000026005 (Evidence)
NCBI Gene

66646

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026005	Ensembl Gene Model \| MGI Sequence Detail	18975	C57BL/6J	± kb
transcript	ENSMUST00000113995	Ensembl \| MGI Sequence Detail	2713	Not Applicable
polypeptide	ENSMUSP00000109628	Ensembl \| MGI Sequence Detail	235	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014178 ribulose-phosphate 3-epimerase

(term hierarchy)
EC

5.1.3.1
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR026019 Ribulose-phosphate 3-epimerase

IPR000056 Ribulose-phosphate 3-epimerase-like

IPR011060 Ribulose-phosphate binding barrel

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 7

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MGI:1920011

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 12
Earliest

J:322163 Gumaa KA, et al., The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochem J. 1969 Dec;115(5):1009-29
Latest

J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

TSS for Rpe:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7170	Chr1:66740011-66740018 (+)	25 bp
Tssr7171	Chr1:66740021-66740034 (+)	38 bp
Tssr7172	Chr1:66740035-66740057 (+)	56 bp
Tssr7173	Chr1:66744333-66744339 (+)	4,346 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23