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Cldn15 Gene Detail
Summary
  • Symbol
    Cldn15
  • Name
    claudin 15
  • Synonyms
    2210009B08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913103
    NCBI Gene: 60363
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136996723-137004699 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913103
 protein coding gene Chr5:136995470-137004712 (+)
129S1/SvImJ ENSMUSG00200041627
 protein coding gene Chr5:130784376-130793523 (+)
A/J ENSMUSG00195043629
 protein coding gene Chr5:130286997-130296140 (+)
AKR/J ENSMUSG00220047575
 protein coding gene Chr5:129770466-129779628 (+)
BALB/cJ ENSMUSG00180037999
 protein coding gene Chr5:130383625-130392768 (+)
C3H/HeJ ENSMUSG00175036449
 protein coding gene Chr5:132311201-132320343 (+)
C57BL/6NJ ENSMUSG00215045677
 protein coding gene Chr5:130438272-130447514 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005008468
 protein coding gene Chr5:129664045-129673274 (+)
CBA/J ENSMUSG00210006016
 protein coding gene Chr5:131128762-131137905 (+)
DBA/2J ENSMUSG00185050033
 protein coding gene Chr5:134144155-134153298 (+)
FVB/NJ ENSMUSG00205028285
 protein coding gene Chr5:130028546-130037689 (+)
JF1/MsJ ENSUMUG00000052771
 protein coding gene Chr5:137045373-137054544 (+)
LP/J ENSMUSG00230047220
 protein coding gene Chr5:138257608-138266750 (+)
NOD/ShiLtJ ENSMUSG00190035823
 protein coding gene Chr5:130083444-130092586 (+)
NZO/HlLtJ ENSMUSG00225022095
 protein coding gene Chr5:145939216-145948357 (+)
PWK/PhJ ENSLUMG00010015756
 protein coding gene Chr5:128901014-128910290 (+)
SPRET/EiJ ENSMSPG00010028813
 protein coding gene Chr5:132300492-132308463 (+)
WSB/EiJ ENSIUOG00005031054
 protein coding gene Chr5:132740850-132750012 (+)



Homology
more
  • Human Ortholog
    CLDN15, claudin 15
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN15, claudin 15
  • Links
    NCBI Gene ID: 24146
    UniProt: P56746

  • Chr Location
    7q22.1; chr7:101232092-101238820 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and grow normally with an enlarged upper small intestinal phenotype (megaintestine) resulting from enhanced proliferation of normal cryptic cells after weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    7
  • cDNA Data
    29
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60363 NCBI Gene Model | MGI Sequence Detail 7977 C57BL/6J ±  kb
    transcript NM_021719 RefSeq | MGI Sequence Detail 1878 C57BL/6  
    polypeptide Q9Z0S5 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914340, MGI:2141263
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
    • Latest
      J:351645 Audiger C, et al., Mis-expression of GATA6 re-programs cell fate during early hematopoiesis. Cell Rep. 2024 May 28;43(5):114159
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory