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Cldn15
Gene Detail
Symbol

Name
ID
Cldn15
claudin 15
MGI:1913103
Synonyms
2210009B08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:136966616-136975858 bp, + strand
From VEGA annotation of GRCm38

  9243 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CLDN15
Gene Tree: Cldn15

Human
homologs
CLDN15, claudin 15
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 24146
neXtProt AC: NX_P56746

Human Chr (Location): 7q11.22; chr7:101232092-101238820 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and grow normally with an enlarged upper small intestinal phenotype (megaintestine) resulting from enhanced proliferation of normal cryptic cells after weaning.
 
Interactions
Cldn15 interacts with 157 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ion transport, transport
Component bicellular tight junction, cell junction, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cldn15.1, LOC100491602 ; ZFIN cldn15a    NEW 
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023395 (Evidence)
Ensembl Gene Model ENSMUSG00000001739 (Evidence)
Entrez Gene 60363 (Evidence)
UniGene 87202
DFCI TC1576593
DoTS DT.527673
NIA Mouse Gene Index U006313
PDB 4P79
Consensus CDS Project CCDS19758.1
International Mouse Phenotyping Consortium Status Cldn15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023395 VEGA Gene Model | MGI Sequence Detail 9243 C57BL/6J ±  kb
transcript OTTMUST00000056806 VEGA | MGI Sequence Detail 1902 Not Applicable 
polypeptide OTTMUSP00000027347 VEGA | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR008094 Claudin-15
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005542 claudin-15
References
(Earliest) J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
(Latest) J:190580 Lei Z, et al., EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
All references(34)
Other
accession IDs
MGI:1914340, MGI:2141263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory