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Donson Gene Detail
Summary
  • Symbol
    Donson
  • Name
    downstream neighbor of SON
  • Synonyms
    1110025J21Rik, Donson, ORF60
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890621
    NCBI Gene: 60364
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91676808-91688770 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890621
protein coding gene Chr16:91666856-91688891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023047
protein coding gene Chr16:92707778-92719275 (-)
A/J MGP_AJ_G0023015
protein coding gene Chr16:88371320-88382819 (-)
AKR/J MGP_AKRJ_G0022985
protein coding gene Chr16:91040255-91051756 (-)
BALB/cJ MGP_BALBcJ_G0023017
protein coding gene Chr16:88898410-88909909 (-)
C3H/HeJ MGP_C3HHeJ_G0022778
protein coding gene Chr16:91616504-91628036 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023464
protein coding gene Chr16:95699604-95711101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020966
protein coding gene Chr16:86068553-86079967 (-)
CAST/EiJ MGP_CASTEiJ_G0022297
protein coding gene Chr16:92178632-92189902 (-)
CBA/J MGP_CBAJ_G0022747
protein coding gene Chr16:99790136-99801430 (-)
DBA/2J MGP_DBA2J_G0022881
protein coding gene Chr16:88275294-88286793 (-)
FVB/NJ MGP_FVBNJ_G0022855
protein coding gene Chr16:87399847-87411346 (-)
LP/J MGP_LPJ_G0022951
protein coding gene Chr16:92405174-92416671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022876
protein coding gene Chr16:104333966-104347918 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023482
protein coding gene Chr16:91560597-91573970 (-)
PWK/PhJ MGP_PWKPhJ_G0022042
protein coding gene Chr16:88454114-88467527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021872
protein coding gene Chr16:91123724-91135069 (-)
WSB/EiJ MGP_WSBEiJ_G0022349
protein coding gene Chr16:91804389-91818085 (-)



Homology
more
  • Human Ortholog
    DONSON, downstream neighbor of SON
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DONSON, downstream neighbor of SON
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B17, C21orf60, MIMIS, MISSLA
  • Links
    NCBI Gene ID: 29980
    neXtProt AC: NX_Q9NYP3
    UniProt: Q9NYP3

  • Chr Location
    21q22.11; chr21:33577551-33588708 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout is early embryonic lethal. Heterozygous knockout causes no observable phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022960 Ensembl Gene Model | MGI Sequence Detail 11963 C57BL/6J ±  kb
transcript ENSMUST00000023682 Ensembl | MGI Sequence Detail 2365 Not Applicable  
polypeptide ENSMUSP00000023682 Ensembl | MGI Sequence Detail 560 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915899, MGI:2146495
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:63039 Sund NJ, et al., Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/22/2019
MGI 6.14
The Jackson Laboratory