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Rad18
Gene Detail
Symbol

Name
ID
Rad18
RAD18 E3 ubiquitin protein ligase
MGI:1890476
Synonyms
2810024C04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.42 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:112619850-112696686 bp, - strand
From VEGA annotation of GRCm38

  76837 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAD18
Gene Tree: Rad18

Human
homologs
RAD18, RAD18 E3 ubiquitin protein ligase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56852
neXtProt AC: NX_Q9NS91

Human Synonyms: RNF73

Human Chr (Location): 3p25.3; chr3:8877196-8963475 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Spontaneous(1) Targeted(3)
Genomic Mutations involving Rad18 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male mice homozygous for a null allele exhibit age-dependent decrease in fertility, germ cell number, and testes weight with progressive degeneration of seminiferous tubules.
 
Interactions
Rad18 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (46)    Tissues (25)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 3
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rad18    NEW 
Molecular
reagents
All nucleic(47) Genomic(1) cDNA(45) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000017314 (Evidence)
Ensembl Gene Model ENSMUSG00000030254 (Evidence)
Entrez Gene 58186 (Evidence)
UniGene 103812
DFCI TC1580668, TC1592584, TC1603079, TC1625694
DoTS DT.55159252, DT.40153953, DT.55141642, DT.101373754, DT.101311475
NIA Mouse Gene Index U027717
EC 6.3.2.-
Consensus CDS Project CCDS39589.1, CCDS51870.1
International Mouse Phenotyping Consortium Status Rad18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017314 VEGA Gene Model | MGI Sequence Detail 76837 C57BL/6J ±  kb
transcript OTTMUST00000042061 VEGA | MGI Sequence Detail 2577 Not Applicable 
polypeptide OTTMUSP00000018918 VEGA | MGI Sequence Detail 556 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(399 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003034 SAP domain
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR006642 Zinc finger, Rad18-type putative
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000013666 E3 ubiquitin-protein ligase RAD18
References
(Earliest) J:65085 van der Laan R, et al., Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. Genomics. 2000 Oct 1;69(1):86-94
(Latest) J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24
All references(49)
Other
accession IDs
MGI:1919872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory