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Rad18 Gene Detail
Summary
  • Symbol
    Rad18
  • Name
    RAD18 E3 ubiquitin protein ligase
  • Synonyms
    2810024C04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890476
    NCBI Gene: 58186
  • Gene Overview
    MyGene.info: RAD18
Location & Maps
more
  • Sequence Map
    Chr6:112619850-112696686 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      76837 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.42 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAD18, RAD18, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAD18, RAD18, E3 ubiquitin protein ligase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RNF73
  • Links
    NCBI Gene ID: 56852
    neXtProt AC: NX_Q9NS91

  • Chr Location
    3p25.3; chr3:8877196-8963475 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    5
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Rad18
  • Incidental Mutations
Male mice homozygous for a null allele exhibit age-dependent decrease in fertility, germ cell number, and testes weight with progressive degeneration of seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017314 VEGA Gene Model | MGI Sequence Detail 76837 C57BL/6J ±  kb
transcript OTTMUST00000042061 VEGA | MGI Sequence Detail 2577 Not Applicable  
polypeptide OTTMUSP00000018918 VEGA | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    414 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 47
    Genomic 1
    cDNA 45
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1919872
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:65085 van der Laan R, et al., Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18. Genomics. 2000 Oct 1;69(1):86-94
  • Latest
    J:215791 Zeman MK, et al., DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 2014 Jul 21;206(2):183-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory