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Dgke
Gene Detail
Symbol

Name
ID
Dgke
diacylglycerol kinase, epsilon
MGI:1889276
Synonyms
DAGK6
Feature Type
protein coding gene
Genetic Map
Chromosome 11
54.34 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:89035179-89066850 bp, - strand
From VEGA annotation of GRCm38

  31672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2705  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dgke

Human
homologs
Human Homolog DGKE, diacylglycerol kinase, epsilon 64kDa
NCBI Gene ID 8526
neXtProt AC  NX_P52429
Human Synonyms  DAGK5, DAGK6, DGK, NPHS7
Human Chr (Location)  17q22; chr17:56834099-56868675 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DGKE
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(22) Targeted(6)
Genomic Mutations involving Dgke (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null allele exhibit reductions in susceptibility to electroconvulsive shock and arachidonoyldiacylglycerol accumulation in cerebral cortex, and attenuated long-term potentiation in dentate granular cell synapses.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dgke interacts with 415 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intracellular signal transduction, metabolic process, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, diacylglycerol kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(29) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001312 (Evidence)
Ensembl Gene ModelENSMUSG00000000276 (Evidence)
Entrez Gene56077 (Evidence)
UniGene153695
DFCITC1597925, TC1671188, TC1709415
DoTSDT.101364511, DT.101723871, DT.97386177, DT.97389011
NIA Mouse Gene IndexU033255
EC2.7.1.107
Consensus CDS ProjectCCDS25234.1
International Mouse Knockout Project StatusDgke
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001312 VEGA Gene Model | MGI Sequence Detail 31672 C57BL/6J ±  kb
transcript OTTMUST00000002636 VEGA | MGI Sequence Detail 8347 Not Applicable 
polypeptide OTTMUSP00000001301 VEGA | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(473 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
Protein Ontology PR:000006445 diacylglycerol kinase epsilon
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGI:2144693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory