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Dgke Gene Detail
Summary
  • Symbol
    Dgke
  • Name
    diacylglycerol kinase, epsilon
  • Synonyms
    DAGK6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889276
    NCBI Gene: 56077
Location & Maps
more
  • Sequence Map
    Chr11:89035179-89066850 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 54.34 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DGKE, diacylglycerol kinase epsilon
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DGKE, diacylglycerol kinase epsilon
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AHUS7, DAGK5, DAGK6, DGK, NPHS7
  • Links
    NCBI Gene ID: 8526
    neXtProt AC: NX_P52429

  • Chr Location
    17q22; chr17:56834099-56869567 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DGKE associations

Human Disease Mouse Models
       Nephrotic Syndrome, Type 7; NPHS7   OMIM: 615008
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Targeted
    7
  • Genomic Mutations
    4 involving Dgke
  • Incidental Mutations
Homozygotes for a targeted null allele exhibit reductions in susceptibility to electroconvulsive shock and arachidonoyldiacylglycerol accumulation in cerebral cortex, and attenuated long-term potentiation in dentate granular cell synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001312 VEGA Gene Model | MGI Sequence Detail 31672 C57BL/6J ±  kb
transcript OTTMUST00000002636 VEGA | MGI Sequence Detail 8347 Not Applicable  
polypeptide OTTMUSP00000001301 VEGA | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    466 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006445 diacylglycerol kinase epsilon
  • EC
  • InterPro Domains
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR016064 NAD kinase/diacylglycerol kinase-like domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
less
  • All nucleic 33
    cDNA 29
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144693
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory