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Celsr2 Gene Detail
Summary
  • Symbol
    Celsr2
  • Name
    cadherin, EGF LAG seven-pass G-type receptor 2
  • Synonyms
    Adgrc2, EGFL2, flamingo, mfmi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858235
    NCBI Gene: 53883
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108298167-108323383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.02 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    522 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858235
 protein coding gene Chr3:108298164-108323416 (-)
129S1/SvImJ ENSMUSG00200035062
 protein coding gene Chr3:104914181-104939399 (-)
A/J ENSMUSG00195025123
 protein coding gene Chr3:105340631-105365847 (-)
AKR/J ENSMUSG00220028609
 protein coding gene Chr3:103704281-103729499 (-)
BALB/cJ ENSMUSG00180017769
 protein coding gene Chr3:105286703-105311919 (-)
C3H/HeJ ENSMUSG00175029469
 protein coding gene Chr3:104820734-104845954 (-)
C57BL/6NJ ENSMUSG00215022934
 protein coding gene Chr3:105548614-105573830 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025530
 protein coding gene Chr3:102598915-102623652 (-)
CAST/EiJ ENSTCUG00005025936
 protein coding gene Chr3:105822903-105848244 (-)
CBA/J ENSMUSG00210008141
 protein coding gene Chr3:105442610-105467826 (-)
DBA/2J ENSMUSG00185020133
 protein coding gene Chr3:105911949-105937165 (-)
FVB/NJ ENSMUSG00205018473
 protein coding gene Chr3:104478605-104503821 (-)
JF1/MsJ ENSUMUG00000004223
 protein coding gene Chr3:104883063-104908403 (-)
LP/J ENSMUSG00230016629
 protein coding gene Chr3:107827172-107852390 (-)
NOD/ShiLtJ ENSMUSG00190027543
 protein coding gene Chr3:106150018-106175234 (-)
NZO/HlLtJ ENSMUSG00225017059
 protein coding gene Chr3:110328823-110354158 (-)
PWK/PhJ ENSLUMG00010024411
 protein coding gene Chr3:104746454-104771789 (-)
SPRET/EiJ ENSMSPG00010033566
 protein coding gene Chr3:105252392-105277591 (-)
WSB/EiJ ENSIUOG00005004099
 protein coding gene Chr3:105466299-105491520 (-)



Homology
more
  • Human Ortholog
    CELSR2, cadherin EGF LAG seven-pass G-type receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELSR2, cadherin EGF LAG seven-pass G-type receptor 2
  • Synonyms
    ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3
  • Links
    NCBI Gene ID: 1952
    UniProt: Q9HCU4

  • Chr Location
    1p13.3; chr1:109249539-109275751 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Celsr2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    179
  • cDNA Data
    99
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068740 Ensembl Gene Model | MGI Sequence Detail 25217 C57BL/6J ±  kb
    transcript ENSMUST00000090558 Ensembl | MGI Sequence Detail 11113 Not Applicable  
    polypeptide ENSMUSP00000088046 Ensembl | MGI Sequence Detail 2919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 99
      Primer pair 4
      Other 4
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 28
      Diseases 2
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:64424 Usui T, et al., Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999 Sep 3;98(5):585-95
    • Latest
      J:382776 Guo D, et al., Genetic Regulation of Wnt/PCP Components Through Fgf10/Fgfr2/Sox9 Module in Tear Duct Development. Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):30
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory