Celsr2
Gene Detail

Symbol Name ID

Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) MGI:1858235

Synonyms

EGFL2, flamingo, mfmi1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

47.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:108390851-108415552 bp, - strand From VEGA annotation of GRCm38   24702 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr2

Human homologs

Human Homolog		CELSR2, cadherin, EGF LAG seven-pass G-type receptor 2
NCBI Gene ID		1952
neXtProt AC		NX_Q9HCU4
Human Synonyms		CDHF10, EGFL2, Flamingo1, MEGF3
Human Chr (Location)		1p21; chr1:109792641-109818378 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal.

 
Human Diseases Modeled Using Mouse Celsr2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cell adhesion, cell surface receptor signaling pathway, ...
Component	cytoplasm, integral to membrane, ...
Function	calcium ion binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (243)    Tissues (160)    Images (107)
Theiler Stages: 8, 9, 10, 11, 12, 15, 16, 20, 21, 23, 28

Assay Type	Results
RNA in situ	132
In situ reporter (knock in)	73
RT-PCR	38

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(101) cDNA(97) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000007107 (Evidence)
Ensembl Gene Model	ENSMUSG00000068740 (Evidence)
Entrez Gene	53883 (Evidence)
UniGene	39728
DFCI	TC1580180, TC1597013, TC1601051, TC1602079, TC1619729, TC1642867
NIA Mouse Gene Index	U024526
Consensus CDS Project	CCDS17759.1
International Mouse Knockout Project Status	Celsr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007107	VEGA Gene Model | MGI Sequence Detail	24702	C57BL/6J
transcript	OTTMUST00000016431	VEGA | MGI Sequence Detail	10598	Not Applicable
polypeptide	OTTMUSP00000007531	VEGA | MGI Sequence Detail	2919	Not Applicable

All sequences(60) RefSeq(4) UniProt(6)

Polymorphisms

PCR(1) : SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR015919	Cadherin-like
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR022624	Domain of unknown function DUF3497
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR000203	GPS domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
Protein Ontology	PR:000005319	cadherin EGF LAG seven-pass G-type receptor 2

References

(Earliest) J:64424 Usui T, et al., Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999 Sep 3;98(5):585-95
(Latest) J:186312 Sugimura R, et al., Noncanonical wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012 Jul 20;150(2):351-65
All references(44)