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Gene Detail
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
Synonyms EGFL2, flamingo, mfmi1
Feature Type protein coding gene
Genetic Map
Chromosome 3
47.02 cM
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr3:108390851-108415552 bp, - strand
From VEGA annotation of GRCm38

  24702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr2

Human Homolog CELSR2, cadherin, EGF LAG seven-pass G-type receptor 2
NCBI Gene ID 1952
neXtProt AC  NX_Q9HCU4
Human Synonyms  CDHF10, EGFL2, Flamingo1, MEGF3
Human Chr (Location)  1p21; chr1:109250019-109275756 (+)  GRCh38
alleles, and
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal.
Celsr2 interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (33 annotations)
Process cell adhesion, cell surface receptor signaling pathway, ...
Component cytoplasm, integral component of membrane, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Literature Summary: (10 records)
Data Summary: Results (243)    Tissues (164)    Images (107)
Theiler Stages: 8, 9, 10, 11, 12, 15, 16, 20, 21, 23, 27, 28
Assay TypeResults
RNA in situ 132
In situ reporter (knock in) 73
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(102) cDNA(98) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000007107 (Evidence)
Ensembl Gene ModelENSMUSG00000068740 (Evidence)
Entrez Gene53883 (Evidence)
DFCITC1580180, TC1597013, TC1601051, TC1602079, TC1619729, TC1642867
NIA Mouse Gene IndexU024526
Consensus CDS ProjectCCDS17759.1
International Mouse Knockout Project StatusCelsr2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007107 VEGA Gene Model | MGI Sequence Detail 24702 C57BL/6J ±  kb
transcript OTTMUST00000016431 VEGA | MGI Sequence Detail 10598 Not Applicable 
polypeptide OTTMUSP00000007531 VEGA | MGI Sequence Detail 2919 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(106 from dbSNP Build 137)
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR000203 GPS domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
Protein Ontology PR:000005319 cadherin EGF LAG seven-pass G-type receptor 2
References (Earliest) J:64424 Usui T, et al., Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999 Sep 3;98(5):585-95
(Latest) J:201287 Hermle T, et al., Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013 Jan 23;32(2):245-59
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory