Pik3cg
Gene Detail

Symbol Name ID

Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide MGI:1353576

Synonyms

5830428L06Rik, p110gamma, PI3Kgamma, PI(3)Kgamma, PI3K

Feature Type

protein coding gene

Genetic Map

Chromosome 12

13.74 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:32173473-32208659 bp, - strand From VEGA annotation of GRCm38   35187 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cg

Human homologs

Human Homolog		PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
NCBI Gene ID		5294
neXtProt AC		NX_P48736
Human Synonyms		PI3CG, PI3K, PI3Kgamma, PIK3
Human Chr (Location)		7q22.3; chr7:106505924-106547592 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	angiogenesis, chemotaxis, ...
Component	1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex, cytoplasm, ...
Function	1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033083 (Evidence)
Ensembl Gene Model	ENSMUSG00000020573 (Evidence)
Entrez Gene	30955 (Evidence)
DFCI	TC1582206, TC1592325, TC1617320, TC1735662
DoTS	DT.486484, DT.528199, DT.94259737
NIA Mouse Gene Index	U033889
EC	2.7.1.153, 2.7.11.1
Consensus CDS Project	CCDS25870.1
International Mouse Knockout Project Status	Pik3cg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033083	VEGA Gene Model | MGI Sequence Detail	35187	C57BL/6J
transcript	OTTMUST00000082636	VEGA | MGI Sequence Detail	5871	Not Applicable
polypeptide	OTTMUSP00000044316	VEGA | MGI Sequence Detail	1102	Not Applicable

All sequences(65) RefSeq(6) UniProt(7)

Polymorphisms

SNPs(157 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro	IPR002420	Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro	IPR015433	Phosphatidylinositol Kinase
InterPro	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000012722	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

References

(Earliest) J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
(Latest) J:196425 Schmidt C, et al., Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience. 2013 Mar 13;233:44-53
All references(188)

Other accession IDs

MGI:1923289