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Pik3cg Gene Detail
Summary
  • Symbol
    Pik3cg
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Synonyms
    5830428L06Rik, p110gamma, PI3Kgamma, PI(3)Kgamma, PI3Kgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353576
    NCBI Gene: 30955
  • Gene Overview
    MyGene.info: PIK3CG
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:32173473-32208659 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353576
protein coding gene Chr12:32173129-32208677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019669
protein coding gene Chr12:30160177-30209487 (-)
A/J MGP_AJ_G0019636
protein coding gene Chr12:29302316-29339445 (-)
AKR/J MGP_AKRJ_G0019607
protein coding gene Chr12:30234805-30272100 (-)
BALB/cJ MGP_BALBcJ_G0019613
protein coding gene Chr12:29527295-29563013 (-)
C3H/HeJ MGP_C3HHeJ_G0019417
protein coding gene Chr12:30114026-30152767 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020060
protein coding gene Chr12:31108090-31144088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017685
protein coding gene Chr12:28589894-28627196 (-)
CAST/EiJ MGP_CASTEiJ_G0018972
protein coding gene Chr12:25126496-25164883 (-)
CBA/J MGP_CBAJ_G0019389
protein coding gene Chr12:32110370-32148346 (-)
DBA/2J MGP_DBA2J_G0019502
protein coding gene Chr12:29128297-29162909 (-)
FVB/NJ MGP_FVBNJ_G0019493
protein coding gene Chr12:28916392-28952698 (-)
LP/J MGP_LPJ_G0019572
protein coding gene Chr12:30259013-30298605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019528
protein coding gene Chr12:31745843-31783358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020100
protein coding gene Chr12:29761972-29797713 (-)
PWK/PhJ MGP_PWKPhJ_G0018739
protein coding gene Chr12:23879977-23918282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018527
protein coding gene Chr12:24356607-24397681 (-)
WSB/EiJ MGP_WSBEiJ_G0019022
protein coding gene Chr12:29999537-30036430 (-)



Homology
more
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p110gamma, p120-PI3K, PI3CG, PI3K, PI3Kgamma, PIK3
  • Links
    NCBI Gene ID: 5294
    neXtProt AC: NX_P48736
    UniProt: P48736

  • Chr Location
    7q22.3; chr7:106865278-106908978 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 7 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020573 Ensembl Gene Model | MGI Sequence Detail 35187 C57BL/6J ±  kb
    transcript ENSMUST00000156904 Ensembl | MGI Sequence Detail 4805 Not Applicable  
    polypeptide ENSMUSP00000123539 Ensembl | MGI Sequence Detail 1102 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000012722 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
      IPR002420 Phosphatidylinositol 3-kinase, C2 domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923289
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 162
    • Earliest
      J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
    • Latest
      J:265475 Silva MC, et al., Canonical PI3Kgamma signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Nat Commun. 2018 Apr 17;9(1):1513

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory