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Pik3cg Gene Detail
Summary
  • Symbol
    Pik3cg
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Synonyms
    5830428L06Rik, p110gamma, PI3Kgamma, PI(3)Kgamma, PI3Kgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353576
    NCBI Gene: 30955
  • Gene Overview
    MyGene.info: PIK3CG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:32173473-32208659 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p110gamma, p120-PI3K, PI3CG, PI3K, PI3Kgamma, PIK3
  • Links
    NCBI Gene ID: 5294
    neXtProt AC: NX_P48736
    UniProt: P48736

  • Chr Location
    7q22.3; chr7:106865278-106908978 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 7 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    1 images
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033083 VEGA Gene Model | MGI Sequence Detail 35187 C57BL/6J ±  kb
    transcript OTTMUST00000082638 VEGA | MGI Sequence Detail 4805 Not Applicable  
    polypeptide OTTMUSP00000044318 VEGA | MGI Sequence Detail 1102 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      197 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000012722 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
      IPR002420 Phosphatidylinositol 3-kinase, C2 domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923289
    References
    more
    • Summaries
      All 230
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 160
    • Earliest
      J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
    • Latest
      J:259086 Breasson L, et al., PI3Kgamma activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Sci Signal. 2017 Jul 18;10(488)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory