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Pik3cg
Gene Detail
 Symbol
Name
ID
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
MGI:1353576
Synonyms 5830428L06Rik, p110gamma, PI3Kgamma, PI(3)Kgamma, PI3Kgamma
Feature Type protein coding gene
Genetic Map
Chromosome 12
13.74 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:32173473-32208659 bp, - strand
From VEGA annotation of GRCm38

  35187 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cg

Human
homologs
Human Homolog PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
NCBI Gene ID 5294
neXtProt AC  NX_P48736
Human Synonyms  p110gamma, p120-PI3K, PI3CG, PI3K, PI3Kgamma, PIK3
Human Chr (Location)  7q22.3; chr7:106865278-106908978 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.
 
Phenotype Images(1)
Interactions
Pik3cg interacts with 334 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process angiogenesis, chemotaxis, ...
Component 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex, cytoplasm, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033083 (Evidence)
Ensembl Gene ModelENSMUSG00000020573 (Evidence)
Entrez Gene30955 (Evidence)
DFCITC1582206, TC1592325, TC1617320, TC1735662
DoTSDT.486484, DT.528199, DT.94259737
NIA Mouse Gene IndexU033889
EC2.7.1.153, 2.7.11.1
Consensus CDS ProjectCCDS25870.1
International Mouse Knockout Project StatusPik3cg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033083 VEGA Gene Model | MGI Sequence Detail 35187 C57BL/6J ±  kb
transcript OTTMUST00000082638 VEGA | MGI Sequence Detail 4805 Not Applicable 
polypeptide OTTMUSP00000044318 VEGA | MGI Sequence Detail 1102 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(7)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012722 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
References (Earliest) J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
(Latest) J:207434 Li H, et al., PI3Kgamma inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience. 2013 Dec 3;253:89-99
All references(191)
Other
accession IDs
MGI:1923289

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory