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Nr2f2
Gene Detail
 Symbol
Name
ID
Nr2f2
nuclear receptor subfamily 2, group F, member 2
MGI:1352452
Synonyms 9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2
Feature Type protein coding gene
Genetic Map
Chromosome 7
38.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:70351946-70366735 bp, - strand
From VEGA annotation of GRCm38

  14790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f2

Human
homologs
Human Homolog NR2F2, nuclear receptor subfamily 2, group F, member 2
NCBI Gene ID 7026
neXtProt AC  NX_P24468
Human Synonyms  ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2
Human Chr (Location)  15q26; chr15:96325928-96340263 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR2F2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.
 
Human Diseases Modeled Using Mouse Nr2f2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nr2f2 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process anterior/posterior pattern specification, blood vessel morphogenesis, ...
Component nucleus
Function DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (79 records)
Data Summary: Results (731)    Tissues (357)    Images (121)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 18, 19, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 645
Northern blot 18
Western blot 1
RT-PCR 56
RNase protection 2
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(5) cDNA(24) Primer pair(5) Other(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023060 (Evidence)
Ensembl Gene ModelENSMUSG00000030551 (Evidence)
Entrez Gene11819 (Evidence)
DFCITC1576930, TC1588743, TC1603714, TC1665055, TC1708582, TC1748585
NIA Mouse Gene IndexU028699
Consensus CDS ProjectCCDS21358.1, CCDS21359.1
International Mouse Knockout Project StatusNr2f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023060 VEGA Gene Model | MGI Sequence Detail 14790 C57BL/6J ±  kb
transcript OTTMUST00000055587 VEGA | MGI Sequence Detail 4220 Not Applicable 
polypeptide OTTMUSP00000026633 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011405 COUP transcription factor 2
References (Earliest) J:18563 Qiu Y, et al., Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4451-5
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(143)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory