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Nr2f2 Gene Detail
Summary
  • Symbol
    Nr2f2
  • Name
    nuclear receptor subfamily 2, group F, member 2
  • Synonyms
    9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352452
    NCBI Gene: 11819
Location & Maps
more
  • Sequence Map
    Chr7:70351946-70366735 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14790 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR2F2, nuclear receptor subfamily 2 group F member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F2, nuclear receptor subfamily 2 group F member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2
  • Links
    NCBI Gene ID: 7026
    neXtProt AC: NX_P24468

  • Chr Location
    15q26; chr15:96325928-96340263 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nr2f2 mouse models; 1 with human NR2F2 associations

Human Disease Mouse Models
       Diaphragmatic Hernia, Congenital   OMIM: 142340 View 1 model
       Congenital Heart Defects, Multiple Types, 4; CHTD4   OMIM: 615779
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    69 phenotypes from 4 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    2 involving Nr2f2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023060 VEGA Gene Model | MGI Sequence Detail 14790 C57BL/6J ±  kb
transcript OTTMUST00000055587 VEGA | MGI Sequence Detail 4220 Not Applicable  
polypeptide OTTMUSP00000026633 VEGA | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011405 COUP transcription factor 2
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003068 Transcription factor COUP
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 40
    Genomic 5
    cDNA 25
    Primer pair 5
    Other 5

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514
References
more
  • Summaries
    All 153
    Developmental Gene Expression 91
    Diseases 1
    Gene Ontology 14
    Phenotypes 46
  • Earliest
    J:18563 Qiu Y, et al., Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4451-5
  • Latest
    J:227012 Wu SP, et al., Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun. 2015;6:8245

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory