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Nr2f2 Gene Detail
Summary
  • Symbol
    Nr2f2
  • Name
    nuclear receptor subfamily 2, group F, member 2
  • Synonyms
    9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352452
    NCBI Gene: 11819
  • Gene Overview
    MyGene.info: NR2F2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:70351944-70366735 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 38.66 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352452
protein coding gene Chr7:70351944-70366746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032365
protein coding gene Chr7:71780135-71797100 (-)
A/J MGP_AJ_G0032344
protein coding gene Chr7:70237879-70252667 (-)
AKR/J MGP_AKRJ_G0032280
protein coding gene Chr7:71709831-71724602 (-)
BALB/cJ MGP_BALBcJ_G0032356
protein coding gene Chr7:69971687-69986982 (-)
C3H/HeJ MGP_C3HHeJ_G0032069
protein coding gene Chr7:72428783-72443565 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032848
protein coding gene Chr7:74757477-74773358 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029856
protein coding gene Chr7:72977047-72991913 (-)
CAST/EiJ MGP_CASTEiJ_G0031397
protein coding gene Chr7:63188284-63211873 (-)
CBA/J MGP_CBAJ_G0032035
protein coding gene Chr7:77137449-77154784 (-)
DBA/2J MGP_DBA2J_G0032190
protein coding gene Chr7:68913305-68928122 (-)
FVB/NJ MGP_FVBNJ_G0032145
protein coding gene Chr7:69016785-69031430 (-)
LP/J MGP_LPJ_G0032271
protein coding gene Chr7:72958885-72974520 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032182
protein coding gene Chr7:77391594-77410914 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032866
protein coding gene Chr7:71123253-71137915 (-)
PWK/PhJ MGP_PWKPhJ_G0031117
protein coding gene Chr7:62004188-62028498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030958
protein coding gene Chr7:58119247-58144790 (-)
WSB/EiJ MGP_WSBEiJ_G0031515
protein coding gene Chr7:71468949-71484736 (-)



Homology
more
  • Human Ortholog
    NR2F2, nuclear receptor subfamily 2 group F member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F2, nuclear receptor subfamily 2 group F member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARP1, ARP-1, CHTD4, COUPTF2, COUPTFB, COUPTFII, NF-E3, SVP40, TFCOUP2
  • Links
    NCBI Gene ID: 7026
    neXtProt AC: NX_P24468
    UniProt: P24468

  • Chr Location
    15q26.2; chr15:96325928-96340263 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Nr2f2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 5 alleles in 9 genetic backgrounds
    12 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030551 Ensembl Gene Model | MGI Sequence Detail 14792 C57BL/6J ±  kb
    transcript ENSMUST00000032768 Ensembl | MGI Sequence Detail 4222 Not Applicable  
    polypeptide ENSMUSP00000032768 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 5
      cDNA 28
      Primer pair 5
      Other 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 118
      Diseases 2
      Gene Ontology 14
      Phenotypes 52
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:265538 Fu A, et al., Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries. PLoS Genet. 2018 Aug;14(8):e1007488

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory