Nr2f2
Gene Detail

Symbol Name ID

Nr2f2 nuclear receptor subfamily 2, group F, member 2 MGI:1352452

Synonyms

9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

38.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr7:70351946-70366735 bp, - strand From VEGA annotation of GRCm38   14790 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f2

Human homologs

Human Homolog		NR2F2, nuclear receptor subfamily 2, group F, member 2
NCBI Gene ID		7026
neXtProt AC		NX_P24468
Human Synonyms		ARP1, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2
Human Chr (Location)		15q26; chr15:96869157-96883492 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.

 
Human Diseases Modeled Using Mouse Nr2f2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	anterior/posterior pattern specification, blood vessel morphogenesis, ...
Component	nucleus
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (725)    Tissues (354)    Images (119)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 18, 19, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	639
Northern blot	18
Western blot	1
RT-PCR	56
RNase protection	2

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(5) cDNA(23) Primer pair(5) Other(4)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023060 (Evidence)
Ensembl Gene Model	ENSMUSG00000030551 (Evidence)
Entrez Gene	11819 (Evidence)
DFCI	TC1576930, TC1588743, TC1603714, TC1665055, TC1708582, TC1748585
NIA Mouse Gene Index	U028699
Consensus CDS Project	CCDS21358.1, CCDS21359.1
International Mouse Knockout Project Status	Nr2f2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023060	VEGA Gene Model | MGI Sequence Detail	14790	C57BL/6J
transcript	OTTMUST00000055587	VEGA | MGI Sequence Detail	4220	Not Applicable
polypeptide	OTTMUSP00000026633	VEGA | MGI Sequence Detail	414	Not Applicable

All sequences(39) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR003068	Transcription factor COUP
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011405	COUP transcription factor 2

References

(Earliest) J:18563 Qiu Y, et al., Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4451-5
(Latest) J:194470 Davis RB, et al., BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013 Mar;140(6):1272-81
All references(134)

Other accession IDs

MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514