Klra15 Gene Detail

Summary

• Symbol
  Klra15
• Name
  killer cell lectin-like receptor, subfamily A, member 15
• Synonyms
  Ly49O

• Feature Type
  protein coding gene
• IDs
  MGI:1351665
  NCBI Gene: 27423
• Member of
  Klra cluster
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, cytoband F3
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-in allele exhibit impaired natural killer cell mediated cytotoxicity.

Expression

• cDNA Data
  2

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  7
• RefSeq
  2
• UniProt
  1

• NCBI Gene
  27423

Representative Sequences			Length	Strain/Species
transcript	NM_013793	RefSeq | MGI Sequence Detail	1083	129P3/J
polypeptide	NP_038821	RefSeq | MGI Sequence Detail	262	129P3/J

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR016187 C-type lectin fold
  IPR001304 C-type lectin-like
  IPR016186 C-type lectin-like/link domain superfamily
  IPR013600 Ly49-like, N-terminal
  IPR052013 Mouse Killer cell lectin-like receptors
  IPR033992 Natural killer cell receptor-like, C-type lectin-like domain

Molecular
Reagents

• All nucleic 2

  cDNA 2

  
  

  Microarray probesets 1

References

• Summaries
  All 12

  Phenotypes 4
• Earliest
  J:51845 Feldmeyer D, et al., Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci. 1999 Jan;2(1):57-64
• Latest
  J:267211 Wight A, et al., Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11579-11584