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Mpdu1 Gene Detail
Summary
  • Symbol
    Mpdu1
  • Name
    mannose-P-dolichol utilization defect 1
  • Synonyms
    LEC35, SL15, Supl15h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346040
    NCBI Gene: 24070
  • Gene Overview
    MyGene.info: MPDU1
Location & Maps
more
  • Sequence Map
    Chr11:69656697-69662642 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5946 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MPDU1, mannose-P-dolichol utilization defect 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MPDU1, mannose-P-dolichol utilization defect 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15
  • Links
    NCBI Gene ID: 9526
    neXtProt AC: NX_O75352

  • Chr Location
    17p13.1-p12; chr17:7583647-7588212 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MPDU1 associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type IF; CDG1F   OMIM: 609180
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    23
  • Targeted
    3
  • Genomic Mutations
    2 involving Mpdu1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006008 VEGA Gene Model | MGI Sequence Detail 5946 C57BL/6J ±  kb
transcript OTTMUST00000013453 VEGA | MGI Sequence Detail 1321 Not Applicable  
polypeptide OTTMUSP00000006229 VEGA | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010531 mannose-P-dolichol utilization defect 1 protein
  • InterPro Domains
    IPR016817 Mannose-P-dolichol utilization defect 1 protein
    IPR006603 PQ-loop repeat
Molecular
Reagents
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  • All nucleic 140
    Genomic 1
    cDNA 139

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 16
  • Earliest
    J:57450 Miyashita A, et al., Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11. Gene. 1999 Sep 3;237(1):53-60
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory