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Spry3
Gene Detail
Symbol

Name
ID
Spry3
sprouty homolog 3 (Drosophila)
MGI:1345188
Synonyms
LOC236576, sprouty3
Feature Type
protein coding gene
Genetic Map
Chromosome Unknown
Vertebrate
homology
HomoloGene:4265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPRY3
Protein SuperFamily: sprouty homolog protein

Human
homologs
SPRY3, sprouty RTK signaling antagonist 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10251
neXtProt AC: NX_O43610

Human Synonyms: spry-3

Human Chr (Location): XYq28 and Yq12

Interactions
Spry3 interacts with 76 markers (Mir17, Mir20b, Mir21a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (1 annotations)
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (9)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 4
Western blot 3
RT-PCR 2
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO  
Other vertebrate links: Xenbase spry3    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(1)
Other database
links
Entrez Gene 236576 (Evidence)
UniGene 297666
DFCI TC1718405
DoTS DT.87045605
NIA Mouse Gene Index U170664
Sequences
Representative SequencesLengthStrain/SpeciesFlank
transcript NM_001030293 RefSeq | MGI Sequence Detail 4542 C57BL/6 
polypeptide NP_001025464 RefSeq | MGI Sequence Detail 288 C57BL/6 

For the selected sequences
All sequences(10) RefSeq(2) UniProt(1)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015584 protein sprouty homolog 3
References
(Earliest) J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
(Latest) J:197120 Sharma B, et al., Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. J Biol Chem. 2012 Dec 7;287(50):42352-60
All references(19)
Other
accession IDs
MGI:2685237

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory