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Zeb2
Gene Detail
 Symbol
Name
ID
Zeb2
zinc finger E-box binding homeobox 2
MGI:1344407
Synonyms 9130203F04Rik, D130016B08Rik, mKIAA0569, SIP1, Zfhx1b, Zfx1b
Feature Type protein coding gene
Genetic Map
Chromosome 2
27.31 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:44983699-45117395 bp, - strand
From VEGA annotation of GRCm38

  133697 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zeb2

Human
homologs
Human Homolog ZEB2, zinc finger E-box binding homeobox 2
NCBI Gene ID 9839
neXtProt AC  NX_O60315
Human Synonyms  HSPC082, SIP1, SIP-1, SMADIP1, ZFHX1B
Human Chr (Location)  2q22.3; chr2:144384375-144520391 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZEB2
Alleles
and
phenotypes
All alleles(12) : Targeted(7) Gene trapped(5)
 
Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5.
 
Human Diseases Modeled Using Mouse Zeb2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell proliferation in forebrain, central nervous system development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (613)    Tissues (443)    Images (69)
Theiler Stages: 10, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 586
Northern blot 19
Western blot 1
RT-PCR 7
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000012355 (Evidence)
Ensembl Gene ModelENSMUSG00000026872 (Evidence)
Entrez Gene24136 (Evidence)
DFCITC1577479, TC1588208, TC1597641, TC1597839, TC1630498, TC1654416, TC1665052, TC1695764
NIA Mouse Gene IndexU022590, U231177
Consensus CDS ProjectCCDS16020.1
International Mouse Knockout Project StatusZeb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012355 VEGA Gene Model | MGI Sequence Detail 133697 C57BL/6J ±  kb
transcript OTTMUST00000107183 VEGA | MGI Sequence Detail 3976 Not Applicable 
polypeptide OTTMUSP00000059846 VEGA | MGI Sequence Detail 1215 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(16) UniProt(11)
Polymorphisms SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008598 Drought induced 19/ RING finger protein 114
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017618 zinc finger E-box-binding homeobox 2
References (Earliest) J:56271 Verschueren K, et al., SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999 Jul 16;274(29):20489-98
(Latest) J:197761 McKinsey GL, et al., Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98
All references(77)
Other
accession IDs
MGI:2442196, MGI:2442919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory