About   Help   FAQ
Zeb2 Gene Detail
Summary
  • Symbol
    Zeb2
  • Name
    zinc finger E-box binding homeobox 2
  • Synonyms
    9130203F04Rik, D130016B08Rik, mKIAA0569, SIP1, Zfhx1b, Zfx1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344407
    NCBI Gene: 24136
  • Gene Overview
    MyGene.info: ZEB2
  • Alliance
  • Transcription Start Sites
    42 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:44983632-45117395 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 27.31 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    515 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344407
protein coding gene Chr2:44983512-45117442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025718
protein coding gene Chr2:44056916-44196466 (-)
A/J MGP_AJ_G0025694
protein coding gene Chr2:42260012-42396027 (-)
AKR/J MGP_AKRJ_G0025664
protein coding gene Chr2:43558731-43695197 (-)
BALB/cJ MGP_BALBcJ_G0025689
protein coding gene Chr2:42316904-42452791 (-)
C3H/HeJ MGP_C3HHeJ_G0025450
protein coding gene Chr2:43494810-43636053 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026135
protein coding gene Chr2:45367130-45507531 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023541
protein coding gene Chr2:40571029-40705451 (-)
CAST/EiJ MGP_CASTEiJ_G0024915
protein coding gene Chr2:43545545-43685670 (-)
CBA/J MGP_CBAJ_G0025430
protein coding gene Chr2:47088489-47230400 (-)
DBA/2J MGP_DBA2J_G0025561
protein coding gene Chr2:41926210-42060868 (-)
FVB/NJ MGP_FVBNJ_G0025523
protein coding gene Chr2:41736035-41873642 (-)
LP/J MGP_LPJ_G0025649
protein coding gene Chr2:43850075-43988398 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025554
protein coding gene Chr2:47515334-47657122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026193
protein coding gene Chr2:43490737-43626196 (-)
PWK/PhJ MGP_PWKPhJ_G0024656
protein coding gene Chr2:41854883-41991609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024461
protein coding gene Chr2:43566339-43706280 (-)
WSB/EiJ MGP_WSBEiJ_G0024982
protein coding gene Chr2:43680761-43817207 (-)



Homology
more
  • Human Ortholog
    ZEB2, zinc finger E-box binding homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZEB2, zinc finger E-box binding homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC082, SIP1, SIP-1, SMADIP1, ZFHX1B
  • Links
    NCBI Gene ID: 9839
    neXtProt AC: NX_O60315
    UniProt: O60315

  • Chr Location
    2q22.3; chr2:144384375-144520391 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8868
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZEB2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Zeb2 mouse models; 1 with human ZEB2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 10 genetic backgrounds
    17 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026872 Ensembl Gene Model | MGI Sequence Detail 133764 C57BL/6J ±  kb
    transcript ENSMUST00000028229 Ensembl | MGI Sequence Detail 5335 Not Applicable  
    polypeptide ENSMUSP00000028229 Ensembl | MGI Sequence Detail 1259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      20 Sequences
    • InterPro Domains
      IPR008598 Drought induced 19 protein type, zinc-binding domain
      IPR001356 Homeobox domain
      IPR009057 Homeobox-like domain superfamily
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 30
      Primer pair 5
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442196, MGI:2442919
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 52
      Diseases 2
      Gene Ontology 11
      Phenotypes 44
    • Earliest
      J:56271 Verschueren K, et al., SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999 Jul 16;274(29):20489-98
    • Latest
      J:266255 Scavuzzo MA, et al., Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun. 2018 Aug 22;9(1):3356

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory