Zeb2
Gene Detail

Symbol Name ID

Zeb2 zinc finger E-box binding homeobox 2 MGI:1344407

Synonyms

9130203F04Rik, D130016B08Rik, mKIAA0569, SIP1, Zfhx1b, Zfx1b

Feature Type

protein coding gene

Genetic Map

Chromosome 2

27.31 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:44983732-45117395 bp, - strand From VEGA annotation of GRCm38   133664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zeb2

Human homologs

Human Homolog		ZEB2, zinc finger E-box binding homeobox 2
NCBI Gene ID		9839
neXtProt AC		NX_O60315
Human Synonyms		HSPC082, SIP1, SIP-1, SMADIP1, ZFHX1B
Human Chr (Location)		2q22.3; chr2:145141942-145277958 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ZEB2

Alleles and phenotypes

All alleles(12) : Targeted(7) Gene trapped(5)
 

Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5.

 
Human Diseases Modeled Using Mouse Zeb2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cell proliferation in forebrain, central nervous system development, ...
Component	cytoplasm, nucleolus, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (343)    Tissues (213)    Images (45)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	323
Northern blot	12
Western blot	1
RT-PCR	7

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(25) Primer pair(4) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000012355 (Evidence)
Ensembl Gene Model	ENSMUSG00000026872 (Evidence)
Entrez Gene	24136 (Evidence)
DFCI	TC1577479, TC1588208, TC1597641, TC1597839, TC1630498, TC1654416, TC1665052, TC1695764
NIA Mouse Gene Index	U022590, U231177
Consensus CDS Project	CCDS16020.1
International Mouse Knockout Project Status	Zeb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012355	VEGA Gene Model | MGI Sequence Detail	133664	C57BL/6J
transcript	OTTMUST00000029410	VEGA | MGI Sequence Detail	9024	Not Applicable
polypeptide	OTTMUSP00000013256	VEGA | MGI Sequence Detail	1215	Not Applicable

All sequences(109) RefSeq(2) UniProt(12)

Polymorphisms

SNPs(460 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008598	Drought induced 19/ RING finger protein 114
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017618	zinc finger E-box-binding homeobox 2

References

(Earliest) J:56271 Verschueren K, et al., SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999 Jul 16;274(29):20489-98
(Latest) J:189004 Iwafuchi-Doi M, et al., Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
All references(76)

Other accession IDs

MGI:2442196, MGI:2442919