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Zeb2
Gene Detail
Symbol

Name
ID
Zeb2
zinc finger E-box binding homeobox 2
MGI:1344407
Synonyms
9130203F04Rik, D130016B08Rik, mKIAA0569, SIP1, Zfhx1b, Zfx1b
Feature Type
protein coding gene
Genetic Map
Chromosome 2
27.31 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:44983699-45117395 bp, - strand
From VEGA annotation of GRCm38

  133697 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZEB2
Gene Tree: Zeb2

Human
homologs
ZEB2, zinc finger E-box binding homeobox 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9839
neXtProt AC: NX_O60315

Human Synonyms: HSPC082, SIP1, SIP-1, SMADIP1, ZFHX1B

Human Chr (Location): 2q22.3; chr2:144384375-144520393 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZEB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5.
 
Human Diseases Modeled in Mice Using Zeb2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Zeb2 interacts with 499 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell proliferation in forebrain, central nervous system development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (613)    Tissues (443)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 586
Northern blot 19
Western blot 1
RT-PCR 7
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ZEB2 ; Xenbase zeb2 ; ZFIN zeb2a, zeb2b    NEW 
Molecular
reagents
All nucleic(34) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000012355 (Evidence)
Ensembl Gene Model ENSMUSG00000026872 (Evidence)
Entrez Gene 24136 (Evidence)
DFCI TC1695764, TC1665052, TC1577479, TC1588208, TC1630498, TC1654416, TC1597641, TC1597839
NIA Mouse Gene Index U231177, U022590
Consensus CDS Project CCDS16020.1
International Mouse Phenotyping Consortium Status Zeb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012355 VEGA Gene Model | MGI Sequence Detail 133697 C57BL/6J ±  kb
transcript OTTMUST00000029410 VEGA | MGI Sequence Detail 9057 Not Applicable 
polypeptide OTTMUSP00000013256 VEGA | MGI Sequence Detail 1215 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(12) UniProt(11)
Polymorphisms
SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008598 Drought induced 19/ RING finger protein 114
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017618 zinc finger E-box-binding homeobox 2
References
(Earliest) J:56271 Verschueren K, et al., SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999 Jul 16;274(29):20489-98
(Latest) J:219928 Srivatsa S, et al., Sip1 Downstream Effector ninein Controls Neocortical Axonal Growth, Ipsilateral Branching, and Microtubule Growth and Stability. Neuron. 2015 Mar 4;85(5):998-1012
All references(82)
Disease annotation references (1)
Other
accession IDs
MGI:2442196, MGI:2442919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory